Submitted for Publication: January 14, 2011; final revision received May 20, 2011; accepted May 27, 2011.
Published Online: August 8, 2011. doi:10.1001/archophthalmol.2011.216. This article was corrected for errors on September 20, 2011.
Author Contributions: Dr Klein had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Financial Disclosure: A US patent entitled “Nutritional Supplement to Treat Macular Degeneration (patent No. 6,660,297) was issued on December 9, 2003; Dr Ferris is one of the inventors. The patent is owned by Bausch and Lomb. Dr Ferris has assigned his interest in the patent to the US government and receives government compensation.
Funding/Support: This work was supported by the Casey Eye Institute Macular Degeneration Fund (Drs Klein and Francis), Research to Prevent Blindness, New York, New York (Drs Klein and Francis), the Bea Arveson Macular Degeneration Fund (Dr Klein), and the Foundation Fighting Blindness, Owings Mills, Maryland (Dr Francis).
Additional Contributions: We are grateful to all of the participants and investigators of the AREDS and to the AREDS Genetic Repository. We thank the investigators and participants of the CAPT. Maureen Maguire, PhD, provided and facilitated transfer of data for the CAPT validation. Jennifer Maykoski, BS, helped in compiling the data and Genevieve Long, PhD, assisted in preparing and editing the manuscript.