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Research Letters |

Cutaneous γδ T-Cell Lymphoma With Bilateral Ocular and Adnexal Involvement FREE

Manoharan Shunmugam, FRCOphth; Elsie Chan, FRANZCO; David O’Brart, MB BS, DO, FRCS, FRCOphth, MD; Mufaddal T. Moonim, MD, FRCPath; Miles R. Stanford, MB, BChir, FRCOphth; Ana M. S. Morley, BM, BCh, MA, FRCOphth, MD
[+] Author Affiliations

Author Affiliations: Departments of Ophthalmology (Drs Shunmugam, Chan, O’Brart, Stanford, and Morley) and Cellular Pathology (Dr Moonim), St Thomas' Hospital, London, England.


Arch Ophthalmol. 2011;129(10):1379-1381. doi:10.1001/archophthalmol.2011.317.
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Published online

Subcutaneous panniculitis-like γδ T-cell lymphoma (SPTL-GD) is a rare subtype of primary cutaneous non-Hodgkin T-cell lymphoma caused by a clonal proliferation of mature activated cytotoxic γδ T cells.1,2 It typically manifests with skin nodules or plaques over the extremities and has an aggressive clinical course.2 Although rare, reports exist of other metastatic cutaneous T-cell lymphomas with periocular or intraocular manifestations.3,4However, to our knowledge, we report the first case of SPTL-GD manifesting this way. Furthermore, the simultaneous adnexal, intraocular, and neuro-ophthalmic involvement described here has not been reported for any manifestation of ocular lymphoma.

A 62-year-old woman had a 7-month history of bilateral red eyes with blurred vision. She was diagnosed as having bilateral nongranulomatous anterior uveitis and began treatment with topical steroid eyedrops. However, her vision continued to slowly deteriorate and she additionally began to experience night sweats, fevers, and weight loss. Two months later, she also noticed 2 firm swellings by her right eyebrow and described sequential bilateral pupillary enlargement.

When examined at this stage, her visual acuity was counting fingers OD and 20/80 OS. Both pupils measured 4.5 mm and were poorly reactive to light with no light-near dissociation but hypersensitivity to pilocarpine, 0.125%. There was no ptosis, eyelid malposition, proptosis, globe displacement, or limitation of eye movements. Anterior segment examination revealed bilateral punctate epitheliopathy with reduced corneal sensation, corneal edema, and no infiltrates. There were multiple small nongranulomatous keratic precipitates with 2+ to 3+ of anterior chamber cells in both eyes but no fibrin or hypopyon. Views of the posterior segments were difficult but showed no abnormalities.

Facial examination revealed 2 right subbrow, subcutaneous lesions that were well circumscribed, firm, nontender, and immobile (Figure 1A). No lymph nodes were palpable, and no other systemic abnormalities were detected. However, during the ensuing weeks, 2 other smaller subcutaneous masses developed around the right lower punctum and left cheek.

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Figure 1. Clinical photograph demonstrating 2 firm, nontender subcutaneous masses below the medial end of the right eyebrow with right lower eyelid erythema (A), and an axial T1-weighted magnetic resonance image of the orbit with gadolinium infusion and fat suppression showing smooth perineural enhancement of both intraorbital optic nerve sheaths (arrows) (B).

Her erythrocyte sedimentation rate, C-reactive protein level, full blood cell count, and renal and liver function test results were normal except for an increased platelet count of 679 × 103/μL (reference range, 150-400 × 103/μL; to convert to ×109/L, multiply by 1.0) and a serum angiotensin-converting enzyme level of 124 U/L (reference range, 8-65 U/L; to convert to nanokatals per liter, multiply by 16.667). Computed tomographic scans of the head, chest, abdomen, and pelvis were normal, but magnetic resonance imaging of the head revealed smooth perineural enhancement of both optic nerve sheaths along their intraorbital portion (Figure 1B). An anterior chamber paracentesis was performed and fluid was negative for herpes simplex virus, varicella-zoster virus, cytomegalovirus, and Epstein-Barr virus DNA on polymerase chain reaction. Insufficient sample was available for cytology.

Excisional biopsies of the right subbrow lesions were performed; they were difficult to interpret because of severe necrosis. However, subsequent specimens from the left cheek and right lower eyelid lesions confirmed SPTL-GD (Figure 2). Lesional T cells expressed CD3, CD7, CD30, perforin, TIA-1, and granzyme B and were negative for CD4, CD8, CD56, T-cell receptor α/β (BF-1), and Epstein-Barr virus–encoded small RNA on immunophenotyping/in situ hybridization. The proliferation index as assessed by MIB-1 was 90%.

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Figure 2. Pleomorphic lymphoma cells with fat rimming and lipomembranous change in a necrotic background (hematoxylin-eosin) (A), with the cells expressing CD3 (B), CD30 (C), and perforin (D) (original magnification ×40).

Ophthalmic manifestations of lymphoma are broad and include both ocular adnexal and intraocular disease. Most are B-cell non-Hodgkin lymphomas, although the intraocular and adnexal manifestations relate to different subtypes and do not coexist.5 T-cell lymphomas, including primary cutaneous ones, have also been reported to involve the eye. Typically, they have eyelid involvement and occasionally have intraocular manifestations such as nonspecific uveitis or retinal infiltrates.3 Our case is unusual owing to the simultaneous manifestation of ocular adnexal, intraocular, and neuro-ophthalmic pathologic findings. Although the only biopsy-proven site of involvement in our case was the ocular adnexae, both papillitis and infiltrative optic neuropathy have separately been reported with cutaneous T-cell lymphoma, as have anterior uveitis, corneal involvement, and pupillary dilation.3,4 Finally, SPTL-GD as a specific subtype of cutaneous T-cell lymphoma has previously been reported only with extraocular muscle involvement.6

Correspondence: Dr A. M. S. Morley, Department of Ophthalmology, St Thomas' Hospital, Westminster Bridge Road, London SE1 7EH, England (susie.morley@gstt.nhs.uk).

Financial Disclosure: None reported.

Additional Contributions: Ata Siddiqui, FRCR, helped with the radiological imaging.

Willemze R, Jaffe ES, Burg G,  et al.  WHO-EORTC classification for cutaneous lymphomas.  Blood. 2005;105(10):3768-3785
PubMed   |  Link to Article
Willemze R, Jansen PM, Cerroni L,  et al; EORTC Cutaneous Lymphoma Group.  Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group study of 83 cases.  Blood. 2008;111(2):838-845
PubMed   |  Link to Article
Cook BE Jr, Bartley GB, Pittelkow MR. Ophthalmic abnormalities in patients with cutaneous T-cell lymphoma.  Ophthalmology. 1999;106(7):1339-1344
PubMed   |  Link to Article
Levy-Clarke GA, Greenman D, Sieving PC,  et al.  Ophthalmic manifestations, cytology, immunohistochemistry, and molecular analysis of intraocular metastatic T-cell lymphoma: report of a case and review of the literature.  Surv Ophthalmol. 2008;53(3):285-295
PubMed   |  Link to Article
Leonard GD, Hegde U, Butman J, Jaffe ES, Wilson WH. Extraocular muscle palsies in subcutaneous panniculitis-like T-cell lymphoma.  J Clin Oncol. 2003;21(15):2993-2995
PubMed   |  Link to Article
Coupland SE, Damato B. Lymphomas involving the eye and the ocular adnexa.  Curr Opin Ophthalmol. 2006;17(6):523-531
PubMed

Figures

Place holder to copy figure label and caption
Graphic Jump Location

Figure 1. Clinical photograph demonstrating 2 firm, nontender subcutaneous masses below the medial end of the right eyebrow with right lower eyelid erythema (A), and an axial T1-weighted magnetic resonance image of the orbit with gadolinium infusion and fat suppression showing smooth perineural enhancement of both intraorbital optic nerve sheaths (arrows) (B).

Place holder to copy figure label and caption
Graphic Jump Location

Figure 2. Pleomorphic lymphoma cells with fat rimming and lipomembranous change in a necrotic background (hematoxylin-eosin) (A), with the cells expressing CD3 (B), CD30 (C), and perforin (D) (original magnification ×40).

Tables

References

Willemze R, Jaffe ES, Burg G,  et al.  WHO-EORTC classification for cutaneous lymphomas.  Blood. 2005;105(10):3768-3785
PubMed   |  Link to Article
Willemze R, Jansen PM, Cerroni L,  et al; EORTC Cutaneous Lymphoma Group.  Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group study of 83 cases.  Blood. 2008;111(2):838-845
PubMed   |  Link to Article
Cook BE Jr, Bartley GB, Pittelkow MR. Ophthalmic abnormalities in patients with cutaneous T-cell lymphoma.  Ophthalmology. 1999;106(7):1339-1344
PubMed   |  Link to Article
Levy-Clarke GA, Greenman D, Sieving PC,  et al.  Ophthalmic manifestations, cytology, immunohistochemistry, and molecular analysis of intraocular metastatic T-cell lymphoma: report of a case and review of the literature.  Surv Ophthalmol. 2008;53(3):285-295
PubMed   |  Link to Article
Leonard GD, Hegde U, Butman J, Jaffe ES, Wilson WH. Extraocular muscle palsies in subcutaneous panniculitis-like T-cell lymphoma.  J Clin Oncol. 2003;21(15):2993-2995
PubMed   |  Link to Article
Coupland SE, Damato B. Lymphomas involving the eye and the ocular adnexa.  Curr Opin Ophthalmol. 2006;17(6):523-531
PubMed

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