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Research Letters |

Vitelliform Retinopathy in Metastatic Cutaneous Melanoma With Choroidal Involvement FREE

Rahul N. Khurana, MD; Mark R. Wieland, MD; Edwin E. Boldrey, MD; David A. Lewis, MD; Daniel M. Albert, MD
[+] Author Affiliations

Author Affiliations: Department of Ophthalmology, University of California, San Francisco (Dr Khurana), and Northern California Retina Vitreous Associates, Mountain View (Drs Khurana, Wieland, and Boldrey); and Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison (Drs Lewis and Albert).


Arch Ophthalmol. 2011;129(11):1498-1499. doi:10.1001/archophthalmol.2011.311.
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Published online

Vitelliform retinopathy has been reported in patients with metastatic melanoma.17 Without clinical evidence of choroidal involvement, it has been speculated to be of paraneoplastic origin.37 We describe vitelliform lesions in a patient with metastatic cutaneous melanoma with histopathologic evidence of choroidal metastasis.

A 73-year-old man was referred for nyctalopia in January 1994. He denied having photopsias. His medical history was significant for metastatic cutaneous melanoma that was in remission. His best-corrected visual acuity was 20/30 OU. Slitlamp examination results were unremarkable. Funduscopic examination showed multiple neurosensory and retinal pigment epithelial (RPE) detachments of varying size (500-5000 μm) in both eyes (Figure 1). There were layered fluid-lipid interfaces inferiorly in the larger RPE detachments. Fluorescein angiography demonstrated bilateral areas of blocked fluorescence secondary to the fundus lesions, and there was early leakage into the overlying RPE detachment. Echographic examination did not reveal choroidal infiltration.

Place holder to copy figure label and caption
Graphic Jump Location

Figure 1. Funduscopic examination shows multiple neurosensory and retinal pigment epithelial detachments of varying size (500-5000 μm) in both eyes. There is a layered fluid-lipid interface inferiorly in some of the retinal pigment epithelial detachments.

Results of a systemic metastatic workup were negative; however, 16 months later, a magnetic resonance image of the head revealed metastatic lesions involving the parietal lobe. During the next 18 months, his visual acuity remained stable and the neurosensory and RPE detachments resolved. Two years after his initial examination, his visual acuity had deteriorated to 20/70 OU with the presence of atrophy of the RPE and pigmentary changes involving the RPE in the fovea.

Despite chemotherapy and radiation, the patient died of metastatic cutaneous melanoma 3 years after the initial diagnosis. His right eye was enucleated after death and was submitted for pathologic examination. Histologically, there was a flat, pigmented, cellular infiltrate within the choroid located just posterior to the equator. The infiltrate was composed of a dense population of spindle-shaped and epithelioid cells with pale cytoplasm and marked nuclear and cellular pleomorphism. Rare mitotic figures were seen in the mass. Large blood vessels coursed throughout the tumor. These findings were consistent with metastatic melanoma involving the choroid. In addition, multiple, small RPE detachments were overlying the tumor (Figure 2).

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Graphic Jump Location

Figure 2. Histopathologic findings. A, Just posterior to the equator, a relatively flat, pigmented, cellular infiltrate is seen within the choroid. The tumor is 500 mm thick and tapers at the ends (hematoxylin-eosin, original magnification ×2). B, The infiltrate displays a dense population of spindle-shaped and epithelioid melanoma cells with pale cytoplasm that demonstrates marked cellular and nuclear pleomorphism. Several small retinal pigment epithelial detachments are seen overlying the tumor (arrows). The retina is artifactually detached and not visible (hematoxylin-eosin, original magnification ×20).

Melanoma-associated retinopathy (MAR) is a rare paraneoplastic condition in patients with metastatic melanoma associated with nyctalopia, visual photopsias, abnormal electroretinographic findings, and antiretinal antibodies. Funduscopy findings in MAR are typically normal, although recently many retinal findings including vitelliform lesions have been described.17 The etiology of this vitelliform retinopathy is unknown. Optical coherence tomography of these lesions suggests that they are at the level of the outer retina and RPE without choroidal involvement.5,6 Because there is no clinical evidence of choroidal involvement, the vitelliform retinopathy is speculated to be paraneoplastic in origin and a variant of MAR.37

To our knowledge, this is the first histologic report of vitelliform retinopathy in metastatic cutaneous melanoma. Although there was no clinical evidence of choroidal metastasis (fundus examination, fluorescein angiography, ultrasonography), the histopathologic findings confirm choroidal infiltration. Clinically, the patient had nyctalopia, which would be consistent with MAR, but electroretinography and antiretinal antibody testing were not performed. Previous cases of vitelliform retinopathy have had some clinical findings consistent with MAR,1,2,4,6 while others have not.4,5 None of these reports had clinical evidence of choroidal involvement. The vitelliform lesions have been postulated to represent a new paraneoplastic clinical manifestation. The pathologic results in this case argue against a paraneoplastic entity but may suggest a local metastatic cause with subclinical choroidal involvement. Another explanation is that choroidal involvement occurred after the vitelliform lesions with the dissemination of the metastatic melanoma. Further studies are needed to determine the etiology of these vitelliform lesions in metastatic melanoma.

Correspondence: Dr Khurana, Northern California Retina Vitreous Associates, 2485 Hospital Dr, Ste 200, Mountain View, CA 94040 (rnkhurana@gmail.com).

Financial Disclosure: None reported.

Zacks DN, Pinnolis MK, Berson EL, Gragoudas ES. Melanoma-associated retinopathy and recurrent exudative retinal detachments in a patient with choroidal melanoma.  Am J Ophthalmol. 2001;132(4):578-581
PubMed   |  Link to Article
Palmowski AM, Haus AH, Pföhler C,  et al.  Bilateral multifocal chorioretinopathy in a woman with cutaneous malignant melanoma.  Arch Ophthalmol. 2002;120(12):1756-1761
PubMed
Jampol LM, Kim HH, Bryar PJ, Shankle JB, Lee RT, Johnston RL. Multiple serous retinal detachments and subretinal deposits as the presenting signs of metastatic melanoma.  Retina. 2004;24(2):320-322
PubMed   |  Link to Article
Sotodeh M, Paridaens D, Keunen J, van Schooneveld M, Adamus G, Baarsma S. Paraneoplastic vitelliform retinopathy associated with cutaneous or uveal melanoma and metastases.  Klin Monbl Augenheilkd. 2005;222(11):910-914
PubMed   |  Link to Article
Nieuwendijk TJ, Hooymans JM. Paraneoplastic vitelliform retinopathy associated with metastatic choroidal melanoma.  Eye (Lond). 2007;21(11):1436-1437
PubMed   |  Link to Article
Javaheri M, Khurana RN, Bhatti RA, Lim JI. Optical coherence tomography findings in paraneoplastic pseudovitelliform lesions in melanoma-associated retinopathy.  Clin Ophthalmol. 2008;2(2):461-463
PubMed
Eksandh L, Adamus G, Mosgrove L, Andréasson S. Autoantibodies against bestrophin in a patient with vitelliform paraneoplastic retinopathy and a metastatic choroidal malignant melanoma.  Arch Ophthalmol. 2008;126(3):432-435
PubMed   |  Link to Article

Figures

Place holder to copy figure label and caption
Graphic Jump Location

Figure 1. Funduscopic examination shows multiple neurosensory and retinal pigment epithelial detachments of varying size (500-5000 μm) in both eyes. There is a layered fluid-lipid interface inferiorly in some of the retinal pigment epithelial detachments.

Place holder to copy figure label and caption
Graphic Jump Location

Figure 2. Histopathologic findings. A, Just posterior to the equator, a relatively flat, pigmented, cellular infiltrate is seen within the choroid. The tumor is 500 mm thick and tapers at the ends (hematoxylin-eosin, original magnification ×2). B, The infiltrate displays a dense population of spindle-shaped and epithelioid melanoma cells with pale cytoplasm that demonstrates marked cellular and nuclear pleomorphism. Several small retinal pigment epithelial detachments are seen overlying the tumor (arrows). The retina is artifactually detached and not visible (hematoxylin-eosin, original magnification ×20).

Tables

References

Zacks DN, Pinnolis MK, Berson EL, Gragoudas ES. Melanoma-associated retinopathy and recurrent exudative retinal detachments in a patient with choroidal melanoma.  Am J Ophthalmol. 2001;132(4):578-581
PubMed   |  Link to Article
Palmowski AM, Haus AH, Pföhler C,  et al.  Bilateral multifocal chorioretinopathy in a woman with cutaneous malignant melanoma.  Arch Ophthalmol. 2002;120(12):1756-1761
PubMed
Jampol LM, Kim HH, Bryar PJ, Shankle JB, Lee RT, Johnston RL. Multiple serous retinal detachments and subretinal deposits as the presenting signs of metastatic melanoma.  Retina. 2004;24(2):320-322
PubMed   |  Link to Article
Sotodeh M, Paridaens D, Keunen J, van Schooneveld M, Adamus G, Baarsma S. Paraneoplastic vitelliform retinopathy associated with cutaneous or uveal melanoma and metastases.  Klin Monbl Augenheilkd. 2005;222(11):910-914
PubMed   |  Link to Article
Nieuwendijk TJ, Hooymans JM. Paraneoplastic vitelliform retinopathy associated with metastatic choroidal melanoma.  Eye (Lond). 2007;21(11):1436-1437
PubMed   |  Link to Article
Javaheri M, Khurana RN, Bhatti RA, Lim JI. Optical coherence tomography findings in paraneoplastic pseudovitelliform lesions in melanoma-associated retinopathy.  Clin Ophthalmol. 2008;2(2):461-463
PubMed
Eksandh L, Adamus G, Mosgrove L, Andréasson S. Autoantibodies against bestrophin in a patient with vitelliform paraneoplastic retinopathy and a metastatic choroidal malignant melanoma.  Arch Ophthalmol. 2008;126(3):432-435
PubMed   |  Link to Article

Correspondence

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