In 1968, Nirankari et al8 described a 57-year-old man who underwent evisceration for panophthalmitis from undetected uveal melanoma. He developed vitiligo at 9 years and orbital recurrence of uveal melanoma at 11 years, for which orbital exenteration was performed. In 1982, Albert et al6 described 2 patients with skin depigmentation following enucleation for melanoma. Case 1 was a 69-year-old man who developed vitiligo 5 years after enucleation, and case 2 was a 36-year-old man who developed cutaneous halo nevi 1 year after enucleation. Albert and colleagues speculated that this represented a heightened host response and more favorable prognosis. In 2004, Duh et al7 described a 74-year-old woman with a 12.8-mm-thick uveal melanoma who developed vitiligo 6 years after enucleation. These reports suggest a possible role of the immune system following therapy of uveal melanoma, similar to cutaneous melanoma. We are not aware of other cases of cutaneous halo nevi developing after plaque radiotherapy for uveal melanoma.