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Research Letters |

Cutaneous Halo Nevi Following Plaque Radiotherapy for Uveal Melanoma FREE

Ahmet M. Sarici, MD; Sanket U. Shah, MD; Carol L. Shields, MD; Richard H. Birdsong, MD; Jerry A. Shields, MD
[+] Author Affiliations

Author Affiliations: Department of Ocular Oncology, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania (Drs Sarici, Shah, C. L. Shields, and J. A. Shields); and Department of Ophthalmology, Walter Reed Army Medical Center, Washington, DC (Dr Birdsong).


Arch Ophthalmol. 2011;129(11):1499-1501. doi:10.1001/archophthalmol.2011.313.
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Halo nevi have been described in both dermatology and ophthalmology.1,2 Cutaneous halo nevi are found more often in children than adults and are believed to result from an immune response.3 Choroidal halo nevus represents 5% of all choroidal nevi and displays low risk for transformation to melanoma.4 The development of cutaneous halo nevi or vitiligo in adulthood can occur following treatment of cutaneous melanoma and correlates with decreased morbidity, presumably due to activation of a systemic immune response.5 There have been rare reports of vitiligo and/or cutaneous halo nevi development following enucleation for uveal melanoma.6,7 A comprehensive study on choroidal halo nevi found a statistical association with history of skin melanoma.2 Herein, we describe a young woman with uveal melanoma who developed a halo ring around numerous pigmented cutaneous nevi following plaque radiotherapy for uveal melanoma.

A 28-year-old woman with photopsia in the left eye was diagnosed as having choroidal melanoma. There was no history of cutaneous melanoma. Visual acuity was 20/20 OD and 20/25 OS. The melanoma measured 14 mm in basal dimension and 7 mm in thickness (Figure, A).

Place holder to copy figure label and caption
Graphic Jump Location

Figure. Cutaneous halo nevi development following plaque radiotherapy for uveal melanoma. A, Wide-angle fundus photograph of the left eye in a 28-year-old woman shows a ciliochoroidal melanoma. B-E, Four months after treatment with iodine 125 plaque radiotherapy, halo (arrows) around multiple cutaneous nevi involving the face, neck, upper chest, and back were documented, with almost complete depigmentation of 1 of the nevi (arrowhead) (B).

Iodine 125 plaque radiotherapy was performed. Two months after therapy, the patient reported development of a noninflammatory, painless, circumscribed halo around numerous previously pigmented cutaneous nevi, and 1 nevus lost nearly all pigmentation (Figure, B-E). At 4 months, the uveal melanoma regressed to 3.7 mm in thickness. Metastatic evaluation findings were negative.

Cutaneous melanoma can stimulate vitiligo or halo nevi through immune mechanisms. The proposed pathophysiology involves cytotoxic T-cell–mediated immune reaction targeted against antigens shared between normal melanocytes and melanoma cells such as MART-1, tyrosinase, gp100, TYRP1, and TYRP2.1 Histopathologically, a lymphohistiocytic infiltrate predominated by CD4 and CD8 T cells has been observed at the margin of such depigmented lesions.1 Immunotherapeutic strategies for cutaneous melanoma have been attempted based on this observation.1

In 1968, Nirankari et al8 described a 57-year-old man who underwent evisceration for panophthalmitis from undetected uveal melanoma. He developed vitiligo at 9 years and orbital recurrence of uveal melanoma at 11 years, for which orbital exenteration was performed. In 1982, Albert et al6 described 2 patients with skin depigmentation following enucleation for melanoma. Case 1 was a 69-year-old man who developed vitiligo 5 years after enucleation, and case 2 was a 36-year-old man who developed cutaneous halo nevi 1 year after enucleation. Albert and colleagues speculated that this represented a heightened host response and more favorable prognosis. In 2004, Duh et al7 described a 74-year-old woman with a 12.8-mm-thick uveal melanoma who developed vitiligo 6 years after enucleation. These reports suggest a possible role of the immune system following therapy of uveal melanoma, similar to cutaneous melanoma. We are not aware of other cases of cutaneous halo nevi developing after plaque radiotherapy for uveal melanoma.

The association of cutaneous halo nevus or vitiligo with treated uveal melanoma could be more frequent because these dermal findings can be subtle, as in our case.

Correspondence: Dr C. L. Shields, Department of Ocular Oncology, Wills Eye Institute, Thomas Jefferson University, 840 Walnut St, Ste 1440, Philadelphia, PA 19107 (carol.shields@shieldsoncology.com).

Financial Disclosure: None reported.

Funding/Support: This study was supported by the Eye Tumor Research Foundation, Philadelphia, Pennsylvania.

Speeckaert R, van Geel N, Vermaelen KV,  et al.  Immune reactions in benign and malignant melanocytic lesions: lessons for immunotherapy.  Pigment Cell Melanoma Res. 2011;24(2):334-344
PubMed   |  Link to Article
Shields CL, Maktabi AM, Jahnle E, Mashayekhi A, Lally SE, Shields JA. Halo nevus of the choroid in 150 patients: the 2010 Henry van Dyke Lecture.  Arch Ophthalmol. 2010;128(7):859-864
PubMed   |  Link to Article
Rhodes A. Neoplasms: benign neoplasias, hyperplasias, and dysplasias of melanocytes. In: Fitzpatrick TB, Eisen A, Wolff K, Freedberg I, Austen KF, eds. Dermatology in General Medicine. New York, NY: McGraw-Hill; 1987:877-918
Shields CL, Furuta M, Berman EL,  et al.  Choroidal nevus transformation into melanoma: analysis of 2514 consecutive cases.  Arch Ophthalmol. 2009;127(8):981-987
PubMed   |  Link to Article
Nordlund JJ, Kirkwood JM, Forget BM, Milton G, Albert DM, Lerner AB. Vitiligo in patients with metastatic melanoma: a good prognostic sign.  J Am Acad Dermatol. 1983;9(5):689-696
PubMed   |  Link to Article
Albert DM, Todes-Taylor N, Wagoner M, Nordlund JJ, Lerner AB. Vitiligo or halo nevi occurring in two patients with choroidal melanoma.  Arch Dermatol. 1982;118(1):34-36
PubMed   |  Link to Article
Duh EJ, Schachat AP, Albert DM, Patel SM. Long-term survival in a patient with uveal melanoma and liver metastasis.  Arch Ophthalmol. 2004;122(2):285-287
PubMed   |  Link to Article
Nirankari MS, Khanna KK, Mathur RP. Uveal malignant melanoma with leucoderma.  J All India Ophthalmol Soc. 1968;16(2):63-66
PubMed

Figures

Place holder to copy figure label and caption
Graphic Jump Location

Figure. Cutaneous halo nevi development following plaque radiotherapy for uveal melanoma. A, Wide-angle fundus photograph of the left eye in a 28-year-old woman shows a ciliochoroidal melanoma. B-E, Four months after treatment with iodine 125 plaque radiotherapy, halo (arrows) around multiple cutaneous nevi involving the face, neck, upper chest, and back were documented, with almost complete depigmentation of 1 of the nevi (arrowhead) (B).

Tables

References

Speeckaert R, van Geel N, Vermaelen KV,  et al.  Immune reactions in benign and malignant melanocytic lesions: lessons for immunotherapy.  Pigment Cell Melanoma Res. 2011;24(2):334-344
PubMed   |  Link to Article
Shields CL, Maktabi AM, Jahnle E, Mashayekhi A, Lally SE, Shields JA. Halo nevus of the choroid in 150 patients: the 2010 Henry van Dyke Lecture.  Arch Ophthalmol. 2010;128(7):859-864
PubMed   |  Link to Article
Rhodes A. Neoplasms: benign neoplasias, hyperplasias, and dysplasias of melanocytes. In: Fitzpatrick TB, Eisen A, Wolff K, Freedberg I, Austen KF, eds. Dermatology in General Medicine. New York, NY: McGraw-Hill; 1987:877-918
Shields CL, Furuta M, Berman EL,  et al.  Choroidal nevus transformation into melanoma: analysis of 2514 consecutive cases.  Arch Ophthalmol. 2009;127(8):981-987
PubMed   |  Link to Article
Nordlund JJ, Kirkwood JM, Forget BM, Milton G, Albert DM, Lerner AB. Vitiligo in patients with metastatic melanoma: a good prognostic sign.  J Am Acad Dermatol. 1983;9(5):689-696
PubMed   |  Link to Article
Albert DM, Todes-Taylor N, Wagoner M, Nordlund JJ, Lerner AB. Vitiligo or halo nevi occurring in two patients with choroidal melanoma.  Arch Dermatol. 1982;118(1):34-36
PubMed   |  Link to Article
Duh EJ, Schachat AP, Albert DM, Patel SM. Long-term survival in a patient with uveal melanoma and liver metastasis.  Arch Ophthalmol. 2004;122(2):285-287
PubMed   |  Link to Article
Nirankari MS, Khanna KK, Mathur RP. Uveal malignant melanoma with leucoderma.  J All India Ophthalmol Soc. 1968;16(2):63-66
PubMed

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