To salvage vision, chemoreduction with vincristine sulfate, etoposide, carboplatin, and cyclosporine was initiated in June 2005. After 3 courses of chemoreduction, the tumors persisted and grew into the vitreous. In December 2005, the child underwent external beam radiation therapy (EBRT) for persistent retinoblastoma. In October 2006, no retinoblastoma tumor was detected, and complete remission was assumed. However, despite 3 additional cycles of chemotherapy, the tumor recurred in the right eye, which was subsequently enucleated in September 2007. At the 15-month follow-up visit, the patient was well and had no tumor recurrence.