At the 2-week follow-up, the patient had decreased vision and increased pain in the left eye. Examination revealed a large, tender posterior cervical lymph node on the right side, and she appeared systemically ill. The patient was admitted for evaluation for systemic fungal infection and taken to the operating room for pars plana vitrectomy and another intravitreal amphotericin B injection. During surgery, she was found to have a white fluffy vitreous abscess attached to the retina just above the supratemporal arcade; however, results of vitreous culture testing were negative for C albicans. She was treated with 400 mg of amphotericin B lipid complex every other day, 200 mg of oral fluconazole every other day, topical corticosteroids, and cycloplegic eye drops for 5 weeks.