Submitted for Publication: November 11, 2011; final revision received January 19, 2012; accepted January 30, 2012.
The Pediatric Eye Disease Investigator GroupLead Authors/Writing Committee: The following individuals take authorship responsibility for the results: David B. Petersen, MD; Danielle L. Chandler, MSPH; Michael X. Repka, MD, MBA. Additional writing committee members (alphabetical): Roy W. Beck, MD, PhD; Eric R. Crouch III, MD; Katherine A. Lee, MD, PhD; Michele Melia, ScM; David G. Morrison, MD; Faruk H. Orge, MD; Benjamin H. Ticho, MD.
Clinical sites that participated in this protocol: Sites are listed in order by number of patients enrolled into the study. Personnel are listed as (I) for Investigator (C) for Coordinator, and (E) for Examiner. Pediatric Ophthalmology of Erie, Erie PA: Nicholas A. Sala (I); Rhonda M. Hodde (C); Veda L. Zeto (C). St. Luke's Children's Ophthalmology, Boise, ID: Katherine A. Lee (I); Bonita R. Schweinler (C); Larry W. Plum (E). Rocky Mountain Eye Care Associates, Salt Lake City, UT: David B. Petersen (I); J. Ryan McMurtrey (C). Pediatric Ophthalmology and Strabismus Associates, Providence, RI: David Robbins Tien (I); Gi H. Yoon-Huang (I); Myra B. McGuinness (C); Jessica M. De La Rosa (C); Colleen M. Bailey (E); Jo Ann Marinaro (E). The Eye Specialists Center, LLC, Chicago Ridge, IL: Benjamin H. Ticho (I); Alexander J. Khammar (I); Deborah A. Clausius (C); James B. Coletta (C); Barbara C. Imler (E). Pediatric Ophthalmology Associates, Inc at Nationwide Children's Hospital, Columbus, OH*: Don L. Bremer (I); Cybil M. Cassady (I); Richard P. Golden (I); Mary Lou McGregor (I); David L. Rogers (I); Gary L. Rogers (I); Rae R. Fellows (C); Meghan C. McMillin (C); Teresa M. Rinehart (C); Amy J. Wagner (C); Jenny A. Brendez (E); Rich E. Cox (E). Children"s Medical Center, Dallas, TX**: David R. Weakley Jr (I); Clare L. Dias (C); Xiaowei W. Zhang (C). Eastern Virginia Medical School, Norfolk, VA: Earl R. Crouch (I); Eric R. Crouch (I); Gaylord G. Ventura (C). Vanderbilt Eye Center, Nashville, TN**: David G. Morrison (I); Lisa A. Fraine (C); Ronald J. Biernacki (E); Christine C. Franklin (E); Kelsie J. Haskins (E). Everett and Hurite Ophthalmic Association, Cranberry Township, PA: Darren L. Hoover (I); Pamela A. Huston (C). Emory University, Atlanta, GA: Scott R. Lambert (I); Amy K. Hutchinson (I); Phoebe D. Lenhart (I); Marla J. Shainberg (C); Rachel A. Robb (C); Natario L. Couser (E). Concord Eye Care PC, Concord, NH: Christie L. Morse (I); Caroline C. Fang (C); Melanie L. Christian (C); Virginia X. Karlsson (E). Cole Eye Institute, Cleveland, OH**: Elias Traboulsi (I); Paul J. Rychwalski (I); Susan W. Crowe (C). Family Eye Group, Lancaster, PA: David I. Silbert (I); Eric L. Singman (I); Noelle S. Matta (C); Garry L. Leckemby (E); Michael R. Pavlica (E). University of Minnesota, Minneapolis, MN**: C. Gail Summers (I); Erick D. Bothun (I); Inge De Becker (I); Ann M. Holleschau (C); Anna I. de Melo (E); Kathy M. Hogue (E); Kim S. Merrill (E). Houston Eye Associates, Tomball, TX: Aaron M. Miller (I); Jorie L. Jackson (C); Suzanne S. LaRiviere (E). Family & Children's Eye Center of New Mexico, Albuquerque, NM: Todd A. Goldblum (I); Angela Alfaro (C). St. John's Clinic–Eye Specialists, Springfield, MO: Scott Atkinson (I); Crystal L. Trythall (C); Angela B. Hendrickson (E). Ophthalmology Associates of Greater Annapolis, Arnold, MD: John M. Avallone (I); Charlene R. Bryant (C); Wanda E. Peyton (E). Department of Ophthalmology, Rainbow Babies & Children's Hospital, Cleveland, OH: Faruk H. Orge (I); Sara E. Schoeck (I); Beth J. Colon (C); Nina X. Mar (C); Reena S. Vaswani (E). D’Ambrosio Eye Care, Lancaster, MA: Oren L. Weisberg (I); Shannon M. Giansanti (C); Julie M. Kaddy (C).
*Center received support used for this project from an unrestricted grant support from the Ohio Lions Eye Research Foundation, Bellville, Ohio.
**Center received support used for this project from an unrestricted grant from Research to Prevent Blindness Inc, New York, New York.
PEDIG Coordinating Center: Raymond T. Kraker, Roy W. Beck, Christina M. Cagnina-Morales, Danielle L. Chandler, Laura E. Clark, Chelsea Costa, Elise R. Diamond, Quayleen Donahue, Brooke P. Fimbel, Nicole C. Foster, Elizabeth L. Lazar, Stephanie V. Lee, Lee Anne Lester, B. Michele Melia, Pamela S. Moke, Diana E. Rojas.
National Eye Institute, Bethesda, MD: Donald F. Everett.
NLD3 Planning Committee: Michael X. Repka, Katherine A. Lee, Jonathan M. Holmes, Danielle L. Chandler, Kevin Frick, David I. Silbert, Nicholas A. Sala, Darren L. Hoover, Roy W. Beck.
NLD3 Steering Committee: Katherine A. Lee, Michael X. Repka, Jonathan M. Holmes, Danielle L. Chandler, Donald F. Everett, Veda Lori Zeto, Rae Fellows, and all participating investigators.
PEDIG Executive Committee (dates listed for members on committee for part of study): Jonathan M. Holmes (chair), Roy W. Beck, Eileen E. Birch, Donald F. Everett, Raymond T. Kraker, Michael X. Repka, Susan A. Cotter, David K. Wallace, David B. Petersen (2010 to present), Laura Enyedi (2011 to present), Darren L. Hoover (2008, 2011 to present), David L. Rogers (2011 to present), Aaron M. Miller (2011 to present), Jorie L. Jackson (2011 to present), Marjean T. Kulp (2010 to present), Benjamin H. Ticho (2010 to present), Eric R. Crouch III (2010-2011), Darron Bacal (2009-2010), Robert Rutstein (2009-2010), Stephen Christiansen (2008-2010), Pamela Huston (2008-2009), Katherine A. Lee (2008-2009), Noelle S. Matta (2008-2009), David Morrison (2008-2009), Mitchell Scheiman (2008).
PEDIG Data and Safety Monitoring Committee (dates listed for members on committee for part of study): Marie Diener-West (chair), John D. Baker, Barry Davis, Velma Dobson (2008-2010), Donald F. Everett, Dale L. Phelps, Stephen Poff, Richard A. Saunders, Lawrence Tychsen.
Financial Disclosure: None reported.
Funding/Support: This study was supported by grants EY011751 and EY018810 from the National Eye Institute, National Institutes of Health, Department of Health and Human Services. Alcon Laboratories, Inc, provided antibiotic eyedrops and antibiotic/corticosteroid eyedrops at no cost to the study. The sole purpose was to standardize the drugs used in study; no comparisons were made between drugs.
Disclaimer: The funding organization approved the protocol but had no role in the conduct of the study; in the collection, management, analysis, and interpretation of the data; or in the preparation, review, and approval of the manuscript.