A 55-year-old, nondiabetic, nonhypertensive woman of Asian Indian origin had sudden decreased vision in her left eye for 2 months. Her visual acuity was 20/20 OD and 20/200 OS. The left eye revealed a reddish brown mound of subretinal blood over the posterior pole, about 5 to 6 disc diameters in size. Some of the subretinal hemorrhage was altered and yellow, indicating a long duration (Figure 1A). Indocyanine green angiography revealed a hypofluorescent area corresponding to the area of subretinal blood, and no hot spot was found (Figure 1B). Provisional diagnosis of idiopathic polypoidal choroidopathy causing submacular bleeding was made. The left eye was treated with intravitreous tPA with perfluoropropane gas. Topical anesthesia was achieved with topical proparacaine hydrochloride, 0.5%, ophthalmic eyedrops. Irrigation of the conjunctival cul de sac with povidone-iodine, 5%, was performed. Commercial tPA, diluted with balanced salt solution to a concentration of 100 μg/0.1 mL, and 0.3 mL of pure perfluoropropane gas were then injected via a 30-gauge needle introduced through the pars plana into the vitreous cavity. A paracentesis was then performed to reduce the intraocular pressure. After ensuring optic nerve head perfusion, the eye was covered with a sterile eye pad and the patient was allowed to go home. The patient was advised to maintain a supine position for the first 6 hours to facilitate tPA diffusion through the retina and then remain prone for at least 8 hours a day for 5 days. The next day, the left eye showed complete resolution of the unaltered hemorrhage (Figure 2). Repeated indocyanine green angiography did not show any hot spots. Final best-corrected visual acuity was 20/30 after 2 months.