I am very pleased to introduce “Translational Science with Clinical Promise” to the readers of Archives of Ophthalmology. Translational science involves research in which one applies established knowledge, often from unexpected disciplines, to develop novel therapeutic or diagnostic technology. It is not necessarily focused on the discovery of basic biological principles or mechanisms. Translational science tends to be multidisciplinary. Diverse fields of knowledge must be coordinated because developing clinical treatments is like solving multivariate equations. Many variables have to be identified and optimized to arrive at a solution that is useful clinically. For example, the development of a light-adjustable intraocular lens requires expertise in polymer chemistry, optics, manufacturing, clinical trial design, regulatory affairs, and anterior segment surgery. This multidisciplinary approach is indispensable to product development in the 21st century. The complexity inherent in translational science is mostly hidden inside large companies, which employ medicinal chemists, physicians, statisticians, epidemiologists, and basic scientists. Traditionally in ophthalmology, many of the exciting developments in translational research have been published in the trade journals. There has not been a peer-reviewed journal primarily focused on the most promising emerging therapies and diagnostics in our field until now.