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Research Letters | Aug 2012

Caruncular Alveolar Rhabdomyosarcoma in a Woman Previously Treated for Breast Cancer

Cory Ramstead, MD, FRCSC; Frank Buffam, MD, FRCSC; Valerie White, MD, FRCPC

Arch Ophthalmol. 2012;130(8):1087-1088. doi:10.1001/archophthalmol.2012.313.

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Rhabdomyosarcoma is a malignant mesenchymal tumor that commonly appears in childhood. It is much less frequently seen in adults, and orbital manifestation represents less than 1% of adult cases.¹ We report the case of an alveolar rhabdomyosarcoma that manifested as a caruncular mass in a 54-year-old woman 4 years after treatment for breast carcinoma.

Correspondence: Dr Ramstead, Department of Ophthalmology, University of British Columbia, 203-300 Brae Rd, Duncan, BC V9L 3T8, Canada (ramstead@ualberta.ca).

Financial Disclosure: None reported.

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Figure 1. Photograph demonstrating a right caruncular mass (A), and coronal magnetic resonance image demonstrating the mass (arrow) adjacent to the right medial rectus in the anterior orbit (B).

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Figure 2. Histological analysis shows a sheet of malignant medium-sized cells (hematoxylin-eosin, original magnification ×100) (A) with minimal cytoplasm, pleomorphic nuclei, and numerous mitoses and apoptotic cells (hematoxylin-eosin, original magnification ×400) (B). Immunohistochemical staining is strongly reactive for desmin (immunoperoxidase with hematoxylin counterstain, original magnification ×400) (C) and MyoD1 (immunoperoxidase with hematoxylin counterstain, original magnification ×400) (D), which are both characteristic of rhabdomyosarcoma.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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Ramstead C, Buffam F, White V. Caruncular Alveolar Rhabdomyosarcoma in a Woman Previously Treated for Breast Cancer. Arch Ophthalmol. 2012;130(8):1087-1088. doi:10.1001/archophthalmol.2012.313.

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