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Longitudinal Study of Retinal Nerve Fiber Layer Thickness and Ganglion Cell Complex in Traumatic Optic Neuropathy

Akiyasu Kanamori, MD, PhD; Makoto Nakamura, MD, PhD; Yuko Yamada, MD, PhD; Akira Negi, MD, PhD
Arch Ophthalmol. 2012;130(8):1067-1069. doi:10.1001/archophthalmol.2012.470.
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Extract

Optical coherence tomography (OCT) has been developed to objectively evaluate structural damage in vivo. The tool can be used to evaluate damage to the circumpapillary retinal nerve fiber layer (cpRNFL). Measurements of the cpRNFL play an important role in the diagnosis and management of patients with glaucoma. The recent introduction of spectral-domain OCT has enhanced the scan resolution and provides more reproducibility for image acquisition compared with time-domain OCT, a previous version of OCT. Furthermore, the RTVue (Optovue Inc), one of the spectral-domain OCT instruments, allows us to evaluate inner retinal layer thickness. Reference to the ganglion cell complex (GCC) includes the retinal nerve fiber layer, retinal ganglion cell layer, and inner plexiform layer. Some studies have demonstrated the usefulness of GCC as well as cpRNFL thickness as measured by RTVue in treating glaucomatous eyes.

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Grahic Jump Location

Figure 1. Changes in the optic nerve head map (A) and ganglion cell complex significance (B) of the right eye in case 1. Average circumpapillary retinal nerve fiber layer thickness and ganglion cell complex thickness in each session are also shown. IN indicates inferior nasal; IT, inferior temporal; NL, nasal lower; NT, nasal temporal; NU, nasal upper; SN, superior nasal; ST, superior temporal; T, temporal; TL, temporal lateral; and TU, temporal upper.

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Grahic Jump Location

Figure 2. The time course of the mean (SD) ratio of the affected eyes to the contralateral eyes of circumpapillary retinal nerve fiber layer (cpRNFL) thickness, average ganglion cell complex (GCC), and macular thickness in 4 eyes after traumatic optic neuropathy. *Paired t test, P < .05 compared with the contralateral eyes.

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