Each individual showed a marked reduction in cpRNFL thickness and GCC in TON (Figure 2). The reduction in macular thickness was not as evident, as expected. The cpRNFL thickness and GCC were stable at 1 week after the injury but started to significantly decrease at 2 weeks after the injury (paired t test, cpRNFL, P = .01; GCC, P = .04). Macular thickness started to decrease significantly at 4 weeks after the injury (P = .01). The reduction occurred 2 to 8 weeks after the injury and had almost completely disappeared at 20 weeks. The cpRNFL measurements exhibited significantly greater reductions than did the GCC and macular thickness. The final relative ratio of cpRNFL thickness was 48%, 40%, 57%, and 62% in cases 1 through 4, respectively. The final rate of GCC was 64%, 68%, 71%, and 74% in cases 1 through 4, respectively. The final rate of macular thickness was 90%, 91%, 88%, and 89% in cases 1 through 4, respectively. Although visual acuity in case 3 recovered to 20/20, the relative rates were similar to those of other patients with severe vision loss.