Commentary | ONLINE FIRST

Flashes, Floaters, and Oral Fluoroquinolones ONLINE FIRST

Dennis P. Han, MD; Aniko Szabo, PhD
Arch Ophthalmol. Published online September 01, 2012. doi:10.1001/archophthalmol.2013.559
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Etminan et al1 performed a population-based, retrospective case-control study evaluating the association between retinal detachment (RD) and oral fluoroquinolone use in a population of patients under ophthalmological care. Substantial evidence implicates these agents with tendinitis and tendon rupture, raising a concern that an increased risk of RD might follow from a shared mechanism of collagen degradation2 that could affect the vitreous of the eye. Oral fluoroquinolones are commonly prescribed, possibly even overprescribed,3 such that a public health risk may be posed. However, until now, only anecdotal reports of RD after oral fluoroquinolone use exist. These drugs penetrate rapidly into the vitreous cavity of the eye.4

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