In June 2011, a 38-year-old woman had ocular irritation and foreign body sensation in both eyes (OD > OS) for 2 weeks. She denied ocular pain, diplopia, or a change in visual acuity. Since December 2010, she had attacks of asthma, recurrent sinusitis, episodes of upper gastric pain, and skin rash. A thorough workup revealed granulomas of the lung associated with tissue eosinophilia, peripheral eosinophilia, increased total IgE level, and positive findings for perinuclear antineutrophil cytoplasmic antibodies. Thus, the patient fulfilled the criteria of the American College of Rheumatology to be diagnosed as having CSS with 4 of 6 of the following signs present: asthma, eosinophilia greater than 10% on differential white blood cell count, tissue eosinophilia, nonfixed pulmonary infiltrates, paranasal sinus abnormalities, and mononeuropathy or polyneuropathy. Systemic therapy with corticosteroids and azathioprine was initiated.