Bilateral surgical debulking and blepharoptosis repair were successful (Figure 1B), but recurrent redness, swelling, and irritation persisted despite topical and oral corticosteroids. Because vascular proliferations were prominent histopathologically, bilateral local bevacizumab injections were administered (3.75 mg; 2.5 mg/mL) followed by 3 additional monthly right orbital injections (7.5 mg each). Prophylactic antibiotics, sterile site preparation, and postinjection therapy were not used. Prior to injections, proparacaine hydrochloride eyedrops were administered and a proparacaine-moistened cotton swab was held over the injection sites for 1 minute. To distribute the drug, 2 or 3 separate injections with some movement within the lesion were performed. The injections were well tolerated, without any significant discomfort or pain. Owing to the small dosage of bevacizumab used, it was deemed unlikely to cause hypertension and blood pressure was not measured. Flare-ups ceased while the lesions' sizes remained stable. Nineteen months later, a right-sided flare-up was treated by bevacizumab injection (7.5 mg) that was repeated twice at 1-month intervals. Symptoms improved after the first injection and quiescence was obtained after the second injection; the lesion's size remained stable. The last injection was given prophylactically in the absence of disease activity before the patient's wedding and she has remained without active disease since.