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Translational Science With Clinical Promise | ONLINE FIRST

Improved Clinical Assessment of a Mouse Model of Retinopathy of Prematurity

Marco Zarbin, MD, PhD
Arch Ophthalmol. 2012;130(11):1461. doi:10.1001/jamaophthalmol.2013.676.
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Translational research occupies the interface between basic science and clinical care. Not infrequently, the clinical benefits of a translational research endeavor are indirect. Thus, advances that increase the throughput of data collection or decrease the cost of data collection can have a big impact on the development of clinical treatments because they may increase the screening capacity of a model system and/or reduce the fixed cost structure associated with discovery. In the current issue of Translational Vision Science and Technology, Furtado et al1 describe the use of topical endoscopy fundus imaging to follow the clinical features of oxygen-induced retinopathy in mice, which is a model of retinopathy of prematurity (ROP) developed by Smith et al.2 Topical endoscopy fundus imaging was initially described by Paques et al3 as a means of obtaining high-resolution digital images of the posterior pole of live mice. It involves corneal applanation with a tele-otoscope–digital camera assembly.

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