Surgical Removal of an Atypical Macular Epiretinal Membrane in Neurofibromatosis Type 2: Clinicopathologic Correlation and Visual Outcome

Figure 1. Fundus images of the left eye prior to surgical removal of a dense epiretinal membrane. A, Fundus photograph of a macular lesion of the left eye shows a dense epiretinal membrane with partial obscuration of underlying retinal vessels. A circumlinear disturbance of the deep retina of uncertain nature is visible inferotemporal to the lesion (arrow). B, Fluorescein angiogram shows anomalous vasculature with vessels crossing the horizontal raphe and no obvious foveal avascular zone.

Figure 2. Light microscopical images of a surgically removed epiretinal membrane (original magnification ×400). The membrane folded upon itself during processing. A, Hematoxylin-eosin staining shows relatively marked cellularity of the membrane. The smooth, acellular side of the membrane (arrow) is presumed to be the anterior aspect of the membrane by virtue of surgical observation of tight adhesion to the retina on its posterior aspect and apparent vitreous attachments anteriorly. B, Mild staining for glial fibrillary acidic protein is present (arrows), but without definitive astrocytes noted.