Severe pain can manifest in blind eyes as well as eyes with useful vision.1 Patients who fail conservative therapy with oral analgesics or topical steroid and cycloplegic eyedrops can undergo more aggressive measures. Although enucleation is the definitive treatment, some patients may not be medically or psychologically ready for this.2 As an alternative, retrobulbar alcohol injections can be used. More recently, chlorpromazine, a phenothiazine-class antipsychotic, has gained popularity. Initially described in the 1980s, reports have suggested that it provides superior pain control with a good response rate and fewer complications than alcohol injections.1,3 Previously reported adverse effects due to chlorpromazine injections have all been localized to the intraorbital or periorbital region. Herein, we describe a patient treated with retrobulbar chlorpromazine injection who subsequently developed systemic symptoms similar to those observed in patients receiving enteral chlorpromazine.