At 2 weeks postoperatively, the patient had pain, decreased visual acuity to hand motions, a Seidel-positive cataract incision, plasmoid anterior chamber (AC) reaction, posterior synechia, keratic precipitates, and intraocular pressure of 8 mm Hg OS. There was no retained lens material or plaque present. After review of the literature and informed consent for off-label medication use with the patient, allergist, infectious disease specialist, and pharmacist, the patient was treated with pars plana vitrectomy, AC washout, suture of cataract incision, and injection of intravitreal quinupristin/dalfopristin (0.4 mg/0.1 mL) and ceftazidime (2.25 mg/0.1 mL). He received oral linezolid, 600 mg. Gram staining showed gram-positive cocci in clusters, and the bacteria were coagulase positive. Thirty-six hours later, he had recurrent pain, decreased vision, and reaccumulation of vitreous opacities and hypopyon. S aureus was isolated from the vitreous and AC but sensitivities were pending. Following EVS guidelines for reinjection ( visual acuity <1.5/60 but >light perception,  red reflex absent or increased media opacification compared with the initial manifestation,  at least an equivocal growth seen in the initial culture, and  ≥1 of the following: [A] a 1-mm increase in the height of the hypopyon, [B] a corneal ring infiltrate, and [C] worsening pain), vitrectomy with intravitreal quinupristin/dalfopristin (0.4 mg/0.1 mL) and ceftazidime (2.25 mg/0.1 mL) was performed. The next day, the initial vitreous and AC cultures identified S aureus resistant to methicillin, vancomycin, moxifloxacin, clindamycin, imipenem, and tetracycline but sensitive to chloramphenicol, quinupristin/dalfopristin, and linezolid (determined by Vitek 2 system; BioMérieux, Inc). The second set of cultures showed similar growth. Oral linezolid, 600 mg, and minocycline hydrochloride, 100 mg, were given for 21 days followed by rifampin and minocycline for a total of 3 months. Visual acuity improved to 20/80 at 1 week. Complete resolution of vitreous and AC inflammation as well as return to visual acuity of 20/50 occurred over 3 months.