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Research Letters |

Bilateral Ophthalmic Artery Occlusions Due to Probable Varicella-Zoster Virus Vasculopathy

Hari Jayaram, MA, MRCSEd, MRCOphth, PhD; Dinu Stanescu-Segal, MD, PhD; Graham E. Holder, PhD; Elizabeth M. Graham, FRCP, FRCOphth
Arch Ophthalmol. 2012;130(11):1492-1494. doi:10.1001/archophthalmol.2012.544.
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Varicella-zoster virus (VZV) vasculopathies account for almost one-third of arterial ischemic strokes in children.1 Visual complications are rare, with previous reports occurring secondary to unilateral central retinal artery2 or posterior ciliary artery3 occlusion. We describe the first case, to our knowledge, of an immunocompetent child who became blind due to bilateral ophthalmic artery occlusions secondary to probable VZV vasculopathy.

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Grahic Jump Location

Figure 1. Color fundus photograph and fluorescein angiography. A, Color fundus photograph of the left eye taken 10 days after the initial visit showing diffuse retinal edema and sheathing of the threadlike retinal arteries and veins. B, Fluorescein angiography of the left eye showing patchy areas of reperfused peripheral retina.

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Grahic Jump Location

Figure 2. Electroretinography and magnetic resonance angiography. A, International Society for Clinical Electrophysiology of Vision standard electroretinography performed with gold foil recording electrodes, mydriasis, and Ganzfeld stimulation of the right and left eyes compared with a normal control. No electroretinogram is detectable in the patient under any recording conditions (note the different scales in the patient's data). Flash visual evoked potentials (VEPs) are not definitely detectable and show only residual background noise. DA indicates dark adapted; LA, light adapted. B, Short T1 inversion recovery magnetic resonance angiography of the cerebral vasculature demonstrating an absence of signal within the ophthalmic arteries (arrows). Asterisks indicate the internal carotid artery.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

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