Nov 2012, Vol 130, No. 11 >

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Research Letters | Nov 2012

Topical Linezolid for Refractory Bilateral Mycobacterium chelonae Post–Laser-Assisted In Situ Keratomileusis Keratitis

Rosa Dolz-Marco, MD; Patricia Udaondo, MD; Roberto Gallego-Pinazo, PhD, DiSSO; J. Maria Millán, PhD; Manuel Díaz-Llopis, PhD

Arch Ophthalmol. 2012;130(11):1475-1476. doi:10.1001/archophthalmol.2012.1495.

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Keratitis after laser-assisted in situ keratomileusis (LASIK) caused by Mycobacterium has been widely reported.¹ Different regimens of antibiotic treatments have been published, but fourth-generation fluoroquinolones are the most effective drugs. However, management may be difficult owing to the delay in diagnosis, the long-term antibiotic treatment required in most cases, and the presence of multidrug-resistant pathogens.² Systemic infection by multidrug-resistant Mycobacterium has been successfully treated with linezolid (Zyvoxid), an oxazolidinone antibiotic.³

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Figure 1. Examination after treatment with topical amikacin, clarithromycin, vancomycin hydrochloride, and moxifloxacin revealed large confluent infiltrates in both eyes with satellite lesions.

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Figure 2. After treatment with topical linezolid, complete control of infection was accomplished. The final examination showed a subtle leukoma, larger in the left eye.

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Dolz-Marco R, Udaondo P, Gallego-Pinazo R, Millán J, Díaz-Llopis M. Topical Linezolid for Refractory Bilateral Mycobacterium chelonae Post–Laser-Assisted In Situ Keratomileusis Keratitis. Arch Ophthalmol. 2012;130(11):1475-1476. doi:10.1001/archophthalmol.2012.1495.

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