A 49-year-old immunocompetent white man had gradual vision loss in his left eye. Visual acuity was 20/20 OD and 20/100 OS. Anterior segment examination of the left eye demonstrated small, white, central keratic precipitates but no cells or flare. Fundus examination revealed left temporal retinal vascular occlusive disease, arteriolar and venous sheathing, and peripheral retinal ischemia with neovascularization (Figure, A). The right eye was normal. Complete blood cell count, thrombophilia screen, antinuclear antibody, syphilis serology, and QuantiFERON results were normal. An anterior chamber paracentesis was negative for herpes simplex virus, varicella-zoster virus, and cytomegalovirus by polymerase chain reaction. Chest radiograph and tuberculin skin testing results were normal. Eales disease was diagnosed, scatter laser photocoagulation was applied to areas of ischemic retina, and systemic corticosteroids (60 mg/d) and mycophenolate mofetil (1.5 g/d) were prescribed.