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Translational Science With Clinical Promise | ONLINE FIRST

Treatment of Oxidative Stress With Chelation Therapy

Marco Zarbin, MD, PhD
Arch Ophthalmol. 2012;130(12):1597-1598. doi:10.1001/jamaophthalmol.2013.1306.
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Oxidative stress has been implicated in several age-related eye diseases, including age-related macular degeneration, glaucoma, and diabetic retinopathy, as well as in retinitis pigmentosa. Hahn et al1 have documented higher iron levels in eyes of patients with age-related macular degeneration than in eyes of age-matched controls (particularly chelatable iron deposition in the retinal pigment epithelium and Bruch membrane). Because iron catalyzes the Fenton reaction (which produces hydroxyl radical), these results may mean that iron-mediated oxidative stress contributes to retinal degeneration in age-related macular degeneration. Furthermore, mice deficient in the ferroxidases ceruloplasmin and hephaestin accumulate iron in the retina and subsequently have retinal degeneration with features of age-related macular degeneration.2,3 In these mice, iron chelation with the orally absorbed and cell-permeant iron chelator deferiprone (Ferriprox) ameliorated oxidative stress and protected against iron overload–induced retinal degeneration.4

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