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Research Letters | Dec 2012

Ophthalmologic Diagnosis of Exacerbation of Idiopathic Pulmonary Arterial Hypertension

Dimitra Skondra, MD; Grace C. Chang, MD, PhD; Harrison W. Farber, MD; Dean Eliott, MD

Arch Ophthalmol. 2012;130(12):1619-1621. doi:10.1001/archophthalmol.2012.1802.

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Idiopathic pulmonary arterial hypertension (IPAH; formerly known as primary pulmonary hypertension) is a rare condition usually affecting young to middle-aged women in whom idiopathic obliteration of pulmonary arterioles results in increased pulmonary artery pressure and pulmonary vascular resistance, leading to right heart failure and subsequent elevation in systemic venous pressure.¹ Ocular abnormalities have rarely been reported with IPAH.²^- 6 Herein, we illustrate a case in which ocular findings were the initial manifestation of clinically significant deterioration in a patient with IPAH.

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Figure 1. Clinical photograph, fundus photographs, and fluorescein angiogram. A, External photograph demonstrating bilateral dilated episcleral vessels. B, Montage fundus photograph of the right eye showing rare, subtle, scattered, temporal, peripheral, intraretinal hemorrhages (arrows). C, Montage fundus photograph of the left eye showing a temporal, peripheral, intraretinal hemorrhage (arrow). D, Fluorescein angiogram of the right eye showing mild vessel tortuosity, microaneurysms (arrows), and areas of capillary leakage (arrowhead) in the temporal periphery.

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Figure 2. Spectral-domain optical coherence tomographic images. OD indicates right eye; OS, left eye. A, Serous macular detachment in both eyes at the initial visit. B, Complete resolution of serous macular detachments 7 months after systemic treatment.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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Skondra D, Chang GC, Farber HW, Eliott D. Ophthalmologic Diagnosis of Exacerbation of Idiopathic Pulmonary Arterial Hypertension. Arch Ophthalmol. 2012;130(12):1619-1621. doi:10.1001/archophthalmol.2012.1802.

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