The records of 231 HIV-positive patients were available for review, and data were collected from all visits during this period. The age range of our study population was 22 to 74 years, with a mean age of 47 years. Forty patients (17.3%) were female and 191 patients (82.7%) were male. The most common ocular manifestation of HIV disease was HIV retinopathy, defined by the presence of cotton-wool spots and intraretinal hemorrhages and found in 7 patients (3.0%). Of these patients, 3 were newly diagnosed as having HIV infection, 1 was not currently receiving HAART, 2 recently underwent treatment for systemic AIDS-defining disease, and 1 had a CD4+ lymphocyte count of 7/μL (to convert to ×109 per liter, multiply by 0.001). Herpes simplex virus keratitis was found in 4 patients (1.7%), 3 of whom had epithelial keratitis and 1 of whom had stromal keratitis. One patient (0.4%) had neurosyphilis with ocular involvement. No cases of active CMV retinitis were found, although 8 patients had prior disease. Eight cases of active uveitis (5 anterior and 3 posterior; 3.5%) were found, none of which were immune recovery uveitis or had a confirmed infectious cause despite appropriate testing. Seven of these cases were newly diagnosed and 1 was recurrent and chronic. Two of these 8 patients were newly diagnosed as having HIV infection, and another 2 were not using HAART. Ocular surface neoplasm was found in 1 patient (0.4%): a single case of conjunctival squamous cell carcinoma. One patient had a conjunctival Kaposi sarcoma that had been excised several months prior, when he was diagnosed as having HIV infection; since then, he has been receiving HAART with no recurrences of the conjunctival lesion (Table 1 and Table 2).