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Recombinant T-Cell Receptor Ligands in the Treatment of Uveitis

Marco A. Zarbin, MD, PhD
JAMA Ophthalmol. 2013;131(3):399-400. doi:10.1001/jamaophthalmol.2013.111.
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Uveitis is a major cause of blindness worldwide. Typically, topical and/or systemic corticosteroids are used for the initial treatment of uveitis, but local and systemic adverse effects (eg, cataract, glaucoma, adrenal suppression, and hyperglycemia) may limit long-term use. Alternative immunomodulatory agents include antimetabolites (eg, azathioprine, methotrexate, and mycophenolate mofetil), alkylating agents (eg, cyclophosphamide and chlorambucil), T-cell inhibitors (eg, cyclosporine and tacrolimus), and cytokine inhibitors (eg, infliximab, which blocks tumor necrosis factor-α, and daclizumab, which blocks interleukin-2R). These agents are quite effective, but they too can be associated with serious adverse effects (eg, pancytopenia, hemorrhagic cystitis, opportunistic infections, and lymphoma).

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