A 14-year-old boy presented with a 1-month history of bilateral eye pain, blurry vision, headache, and subjective fevers. On physical examination, he was found to have an erythematous macular rash on his lower extremities. His visual acuity was 20/40 and 20/50 in the right and left eyes, respectively. An ophthalmologic examination revealed bilateral conjunctival injection, with 3+ cell and flare in the anterior chambers. A dilated fundus examination showed 2+ cell in the vitreous and bilateral optic disc edema and serous macular detachments (Figure 2A and B). There was no macular star or exudate. The results of a full uveitis workup were negative for antinuclear antibody, rheumatoid factor, antineutrophil cytoplasmic antibody, HLA-B27, angiotensin-converting enzyme, Lyme disease, syphilis, and B henselae. The erythrocyte sedimentation rate was within normal limits. The results of viral serologic testing for adenovirus, rhinovirus, influenza A and B viruses, and respiratory syncytial virus were also negative. The results of a magnetic resonance imaging/magnetic resonance venography of the brain were within normal limits. A lumbar puncture revealed a normal opening pressure, normal chemistry results, a normal cell count, and a negative culture result. Serology testing for M pneumoniae showed elevated IgM and IgG antibodies. Macular optical coherence tomography revealed peripapillary and macular serous detachments (Figure 3), and fluorescein angiography revealed bilateral optic disc leakage without evidence of leakage in the macula (Figure 4A and B). In addition to topical steroids and cycloplegic eye drops, he was treated with a 1-week course of oral azithromycin. Because his optic disc edema and macular serous detachments persisted for 2 weeks after presentation, he was subsequently treated with 40 mg of oral prednisone daily. One month after presentation, the uveitis and serous macular detachments resolved.