Research Letters |

Transitional Cell Carcinoma of the Lacrimal Sac Presenting With Bloody Tears

Amir A. Azari, MD; Mozhgan R. Kanavi, MD; Noah Saipe, MD; Vivian Lee, MD; Mark Lucarelli, MD; Heather D. Potter, MD; Daniel M. Albert, MD
JAMA Ophthalmol. 2013;131(5):689-690. doi:10.1001/jamaophthalmol.2013.2907.
Text Size: A A A
Published online


Transitional cell carcinomas (TCCs) of the lacrimal sac are uncommon tumors that can have significant morbidity and mortality if not diagnosed and treated in a timely fashion. These tumors have variable clinical and histologic features. Bloody tears, also known as dacryohemorrhea, have been reported only once previously as a presenting sign of the tumor.1 We describe a case of lacrimal sac TCC manifesting with epiphora, dacryohemorrhea, and medial canthal mass.

Figures in this Article

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption
Graphic Jump Location

Figure 1. Computed tomography and intraoperative photograph. A, Orbital computed tomography demonstrates a heterogeneous, relatively well-circumscribed soft-tissue mass, measuring 1.8 × 2.2 × 1.8 cm, centered on the right lacrimal sac fossa. Note bone remodeling of the fossa. B, Intraoperative photograph demonstrates a large mass within the lacrimal sac.

Place holder to copy figure label and caption
Graphic Jump Location

Figure 2. Transitional cell carcinoma of the lacrimal sac. A, Papillary proliferation of transitional cells is seen (hematoxylin-eosin, original magnification ×40). B, Nuclear pleomorphism and mitotic figures are noted (hematoxylin-eosin, original magnification ×400). C, Immunohistochemistry for human papillomavirus 16 demonstrates positive reactivity, suggesting human papillomavirus involvement (immunohistochemical stain for human papillomavirus 16, original magnification ×400).




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Topics
PubMed Articles