A nondiabetic 80-year-old woman had an asymptomatic central retinal vein occlusion in her left eye. It was diagnosed during her scheduled 6-month follow-up visit with her general ophthalmologist. On her initial visit, she was using dorzolamide hydrochloride, 2%, and timolol, 0.5%, combination eyedrops at night in both eyes for her glaucoma. Her visual acuity was 20/20 OU and her intraocular pressure was 14 mm Hg OU. She had retinal hemorrhages in all 4 quadrants with dilated retinal veins. Fluorescein angiography showed a retinal recirculation time of 10 seconds, and the average central foveal thickness with Stratus optical coherence tomography was normal at 218 μm. One month later, her visual acuity decreased to 20/70 OS and she had increased retinal hemorrhage and cystoid macular edema. The retinal veins were dilated, including the tributary connecting the inferotemporal branch retinal vein to the central retinal vein (Figure 1A). The average central foveal thickness on Stratus optical coherence tomography had increased to 511 μm. Fluorescein angiography was not repeated.