Because the patient wished to continue treatment with fingolimod, she began topical treatment with ketorolac tromethamine, 0.5%, and dexamethasone suspension, 0.1%, both 4 times daily in her right eye. After 1 month, BCVA remained at 6/7.5 OD but worsened to 6/9 OS, corresponding to optical coherence tomographic findings of resolving ME in her right eye with progression in her left untreated eye (Figure 1, week 4). To exclude other causes of ME, fluorescein angiography was performed, demonstrating late-phase leakage of dye in the left central macula (Figure 2). At this stage, topical ketorolac and dexamethasone were prescribed for both eyes twice daily with temporary improvement of BCVA to 6/7.5 OU after 3 weeks. Increased instillation frequency of topical anti-inflammatory eyedrops (initially 4 times daily, then every 2 hours) led to resolution of ME (Figure 1, week 23) with improvement of BCVA to 6/6 OU. Unfortunately, attempts at weaning topical anti-inflammatory drugs failed while the patient continued to use fingolimod. After consultation with her neurologist, a decision was made to cease fingolimod use, resulting in resolution of her ME 5 weeks later (Figure 1, week 35).