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Lichen Simplex Chronicus of the Conjunctiva

Heather D. Potter, MD; Vivian Lee, MD; Molly A. Hinshaw, MD; Sherif S. Khedr, MD; Daniel M. Albert, MD; Cat N. Burkat, MD
JAMA Ophthalmol. 2013;131(6):816-818. doi:10.1001/jamaophthalmol.2013.1890.
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Lichen simplex chronicus (LSC) is a disorder commonly encountered by dermatologists, caused by constant rubbing of the skin that clinically induces thickening and lichenification. While a case report of LSC of the eyelids has been published,1 a careful search of the literature did not disclose any prior case of LSC of the palpebral conjunctiva.

Correspondence: Dr Lee, Scheie Eye Institute, University of Pennsylvania, 51 N 39th St, Scheie Room 620, Philadelphia, PA 19104 (vivian.lee@uphs.upenn.edu).

Published Online: April 4, 2013. doi:10.1001/jamaophthalmol.2013.1890

Conflict of Interest Disclosures: None reported.

Funding/Support: This work was supported by grant P30-EY016665 (Core Grant for Vision Research) from the National Institutes of Health and an unrestricted department award from Research to Prevent Blindness.

Additional Contributions: We are grateful for the support from the McPherson Eye Research Institute, University of Wisconsin.

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Figure 1. Slitlamp photograph of the patient's everted left upper eyelid reveals a thickened and keratinized palpebral conjunctiva.

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Figure 2. Elliptical incisional biopsy of the left palpebral conjunctiva demonstrates microscopically a metaplastic conjunctiva showing significant acanthosis, orthokeratosis, and parakeratosis with squamatization. Chronic nongranulomatous inflammation is present in the substantia propria (hematoxylin-eosin, original magnification ×200).

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