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Ophthalmic Images |

Fundus Autofluorescence in Hydroxychloroquine Toxicity

Ian R. Gorovoy, MD; Mark S. Gorovoy, MD
JAMA Ophthalmol. 2013;131(4):506. doi:10.1001/jamaophthalmol.2013.593.
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Fundus autofluorescence images of the left eye of a 59-year-old women with sarcoidosis who received 200 mg of hydroxychloroquine sulfate twice daily for 15 years. Her visual acuity was 20/20 bilaterally with normal red light central 80-point visual fields. A fundus examination demonstrated subtle macular pigmentary change (A). However, autofluorescence revealed bilateral bull’s-eye maculopathies (B). Fundus autofluorescence may also be useful to determine whether patients with macular pigmentary change may continue using hydroxychloroquine because the pigmentary change may be secondary to other nonrelated causes.

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Fundus autofluorescence images of the left eye of a 59-year-old women with sarcoidosis who received 200 mg of hydroxychloroquine sulfate twice daily for 15 years. Her visual acuity was 20/20 bilaterally with normal red light central 80-point visual fields. A fundus examination demonstrated subtle macular pigmentary change (A). However, autofluorescence revealed bilateral bull’s-eye maculopathies (B). Fundus autofluorescence may also be useful to determine whether patients with macular pigmentary change may continue using hydroxychloroquine because the pigmentary change may be secondary to other nonrelated causes.

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