We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Letters |

Histopathologic, Immunohistochemical, and Cytogenetic Analysis of Primary Clear Cell Melanoma of the Uvea

Robert M. Verdijk, MD, PhD; Anna E. Koopmans, MD; Emine Kilic, MD, PhD; Dion Paridaens, MD, PhD; Annelies de Klein, PhD
JAMA Ophthalmol. 2013;131(6):814-816. doi:10.1001/jamaophthalmol.2013.1939.
Text Size: A A A
Published online


The histologic findings of malignant melanoma may be highly variable, and the tumor can mimic many other neoplasms.1 We describe a case of clear cell uveal melanoma. Cytoplasmic clear cell change of uveal melanoma cells can be observed as balloon cells,1 clear cells,2 and signet ring cells.1 The histologic differential diagnosis has to be made with metastatic clear cell carcinomas, seminoma, and clear cell sarcoma as well as xanthomatous cells.

Figures in this Article


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption
Graphic Jump Location

Figure. Ultrasonographic, histologic, and immunohistochemical appearance of the tumor. A, B-scan ultrasonography of the tumor shows a dome-shaped subretinal mass in the posterior pole. B, The tumor was mainly composed of spindle and irregular polygonal cells with distinct borders and a clear cytoplasm that sometimes contained brown pigment. The cells were interspersed in a delicate capillary network. Nuclei were enlarged with coarse open chromatin and prominent irregular nucleoli (hematoxylin-eosin, original magnification ×630). C, The cytoplasm stained positive for periodic acid–Schiff sensitive to diastase treatment (original magnification ×630). D, The cells stained positive for the melanocytic marker HMB-45 (original magnification ×400).




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

2 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.