Submitted for Publication: August 13, 2012; final revision received January 12, 2013; accepted January 14, 2013.
Author Contributions: Drs Suñer, Bressler, Varma, Dolan, and Colman had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Published Online: May 9, 2013. doi:10.1001/jamaophthalmol.2013.114
Conflict of Interest Disclosures: Dr Suñer is a consultant for Bausch & Lomb, Eyetech, Genentech, Optos, and Pfizer. He has received research funding from Genentech and also is on the Medical Advisory Board for Optos. Dr Bressler is principal investigator of grants at Johns Hopkins University and is sponsored by the following entities (not including the National Institutes of Health): Abbott Medical Optics, Alimera Sciences, Allergan, Bausch & Lomb, Carl Zeiss Meditec, DIAGNOS, ForSight Labs, Genentech, Genzyme, Lumenis, Notal Vision, Novartis, Ora, Pfizer, Quark Biotech, Regeneron Pharmaceuticals, Research to Prevent Blindness, Steba Biotech, and the EMMES Corporation. (Note: grants to investigators at Johns Hopkins University are negotiated and administered by the School of Medicine, which receives the grants through the Office of Research Administration. Individual investigators who participate in sponsored projects are not directly compensated by the sponsor but may receive salary or other support from the institution to support their effort on the projects.) Dr Varma is a consultant for Alcon, Allergan, Aquesys, Bausch & Lomb, Genentech, Merck, Replenish, and Pfizer and has received research funds from Allergan, Genentech, Optovue, and Pfizer. Dr Lee is a consultant for Pfizer and Genentech; receives grant support from Alcon, Pfizer, and the National Institutes of Health; and owns stock in Merck, Bristol Meyers Squibb, and Pfizer. Drs Dolan and Ward are paid consultants for Genentech. Drs Colman and Rubio are employees of Genentech.
Funding/Support: The design and conduct of the study, as well as the data collection, management, analysis, and interpretation of the data, and review and approval of the manuscript were supported by Genentech, Inc (South San Francisco, California), and Novartis Pharma AG (Basel, Switzerland). Third-party medical writing logistical assistance, but not editorial content sufficient to meet International Committee of Medical Journal Editors authorship criteria, was provided by Rebecca Jarvis, PhD, of United BioSource Corporation-Envision Group (Southport, Connecticut). Support for third-party writing assistance for this manuscript was provided by Genentech Inc.
Role of the Sponsor: Genentech, Inc, had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Previous Presentation: This study was presented at the Association for Research in Vision and Ophthalmology (ARVO) 2010 Annual Meeting; May 2-6, 2010; Fort Lauderdale, Florida.