0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.204.103.179. Please contact the publisher to request reinstatement.
Observation |

Bilateral Effect of Unilateral Bevacizumab Injection in Retinopathy of Prematurity

Cagatay Karaca, MD1; Ayse Ozturk Oner, MD1; Ertugrul Mirza, MD1; Osman Ahmet Polat, MD1; Mustafa Sahiner, MD1
[+] Author Affiliations
1Department of Ophthalmology, Erciyes University School of Medicine, Kayseri, Turkey
JAMA Ophthalmol. 2013;131(8):1099-1101. doi:10.1001/jamaophthalmol.2013.400.
Text Size: A A A
Published online

Extract

Retinopathy of prematurity (ROP) is a retinal vascular developmental disorder and the leading cause of infant blindness in developed countries.1 Although laser photocoagulation is the gold standard therapy for the management of ROP, it permanently reduces the visual field and might induce myopia with some other rare complications. Off-label use of anti–vascular endothelial growth factor (VEGF) therapy in the form of bevacizumab has recently become popular; however, the ideal dose, adverse effects, and effect on mortality rates remain undetermined.2 Herein, we examined 4 patients with stage 3 ROP (Table) who were treated with a unilateral bevacizumab injection using a sequential laser and showed bilateral regression of ROP. Our findings indicate the systemic escape of bevacizumab from the injected eye and the achievement of significant blood concentrations, which can reduce vascular activity in the contralateral untreated eye.

Figures in this Article

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
/>
First page PDF preview

Figures

Place holder to copy figure label and caption
Figure 1.
Optic Disc and Retina

Fundus photography showing the optic disc and retina of case 4 taken before treatment. A and C, Right eye. B and D, Left eye.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.
Optic Disc and Retina 1 Week After Treatment

Fundus photography showing the optic disc and retina of case 4 taken 1 week after a unilateral injection of bevacizumab to the right eye. Note the bilateral regression of vascular activity. A and C, Right eye. B and D, Left eye.

Graphic Jump Location

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
PubMed Articles
Jobs
brightcove.createExperiences();