We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Research Letter |

Development of a Premacular Vitreous Pocket

Tadashi Yokoi, MD, PhD1; Naoki Toriyama, MD1; Takahiro Yamane, MD, PhD1; Yuri Nakayama, MD1; Sachiko Nishina, MD, PhD1; Noriyuki Azuma, MD, PhD1
[+] Author Affiliations
1Department of Ophthalmology and Cell Biology, National Center for Child Health and Development, Tokyo, Japan
JAMA Ophthalmol. 2013;131(8):1095-1096. doi:10.1001/jamaophthalmol.2013.240.
Text Size: A A A
Published online


The premacular vitreous pocket (PVP), or vitreoschisis cavity, is a liquefied vitreous cavity in front of the posterior retina that is characteristic of various macular diseases, including macular holes and diabetic maculopathy.1 The reason for the development of PVPs is unknown because of the difficulty observing the formed vitreous in vivo. India ink and the fluorescein staining technique have delineated the structure of the PVP in the vitreous cavity in human eyes at autopsy2; however, the technique is limited because of the presence of artifacts during fixation of the fragile and mobile vitreous and postmortem changes. Optical coherence tomography has facilitated observation of the vitreous structures in vivo. Herein, we describe the development and fine details of PVPs in real time.

Figures in this Article

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption
Figure 1.
Age-Dependent Changes in Premacular Vitreous Pockets

A, No premacular vitreous pocket is seen in the eye of a 2-year-old boy. B, A premacular crack in the formed vitreous (arrowheads) is seen in the eye of a 3-year-old girl, and the Cloquet canal is connected to the crack. Premacular vitreous pockets are seen in the eyes of an 8-year-old boy (C), a 13-year-old boy (D), a 30-year-old man (E), and a 54-year-old woman (F), and they are all connected to the Cloquet canal. F, A partial posterior vitreous detachment is seen in the eye of a 54-year-old woman.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.
Multifocal Premacular Vitreous Pockets (PVPs) and Temporal Remnants of Regressed Hyaloid Vessels With a PVP

A-C, Sequential radial sections of the temporal premacular vitreous centered on the optic disc in the eye of a 6-year-old boy. Primitive PVPs are seen superotemporally (A) and inferotemporally (C) but no PVPs are seen temporally (B), indicating that these PVPs are multifocal in origin. D, A regressed hyaloid vessel within both the Cloquet canal and a PVP (arrows) is seen by swept-source optical coherence tomography in the eye of a 5-year-old boy.

Graphic Jump Location




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 1

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles