The premacular vitreous pocket (PVP), or vitreoschisis cavity, is a liquefied vitreous cavity in front of the posterior retina that is characteristic of various macular diseases, including macular holes and diabetic maculopathy.1 The reason for the development of PVPs is unknown because of the difficulty observing the formed vitreous in vivo. India ink and the fluorescein staining technique have delineated the structure of the PVP in the vitreous cavity in human eyes at autopsy2; however, the technique is limited because of the presence of artifacts during fixation of the fragile and mobile vitreous and postmortem changes. Optical coherence tomography has facilitated observation of the vitreous structures in vivo. Herein, we describe the development and fine details of PVPs in real time.
A, No premacular vitreous pocket is seen in the eye of a 2-year-old boy. B, A premacular crack in the formed vitreous (arrowheads) is seen in the eye of a 3-year-old girl, and the Cloquet canal is connected to the crack. Premacular vitreous pockets are seen in the eyes of an 8-year-old boy (C), a 13-year-old boy (D), a 30-year-old man (E), and a 54-year-old woman (F), and they are all connected to the Cloquet canal. F, A partial posterior vitreous detachment is seen in the eye of a 54-year-old woman.
A-C, Sequential radial sections of the temporal premacular vitreous centered on the optic disc in the eye of a 6-year-old boy. Primitive PVPs are seen superotemporally (A) and inferotemporally (C) but no PVPs are seen temporally (B), indicating that these PVPs are multifocal in origin. D, A regressed hyaloid vessel within both the Cloquet canal and a PVP (arrows) is seen by swept-source optical coherence tomography in the eye of a 5-year-old boy.
Thank you for submitting a comment on this article. It will be reviewed by JAMA Ophthalmology editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 1
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.