In March 2010, she presented at the University Eye Hospital Freiburg because of increasing corneal melting with persistent corneal erosion (Figure 1, A and B). Her BCVA was counting fingers. Penetrating limbokeratoplasty was performed. Postoperatively, her BCVA was 10/200 (Figure 1C) and she received immunosuppressive treatment with mycophenolate mofetil.4 Three weeks later, the patient presented with scleritis, transplant erosion, and ocular hypotension. Her BCVA was reduced to 1/50. The patient received prednisolone, 100 mg/d, and cidofovir, 350 mg, intravenously once weekly because reactivation of a CPXV infection was suspected. The ocular changes improved, and the intraocular pressure values became normal, no longer hypotensive, with an epithelialized edematous transplant. Her BCVA was limited to hand movements. The cidofovir therapy was maintained. Cidofovir is, in fact, approved for Cytomegalovirus retinitis in patients with AIDS. The local therapy consisted of dexamethasone sodium phosphate, 1%, every hour. Two weeks later, the patient presented with transplant erosion and decompensated intraocular pressure due to extensive anterior synechiae. Intraocular pressure normalized after operative revision. Epithelialization took place, but the transplant remained bullous. Three months after transplantation, failure of the graft was evident. There was no inflammation.