Submitted for Publication: November 4, 2012; final revision received January 29, 2013; accepted February 6, 2013.
Published Online: June 20, 2013. doi:10.1001/jamaophthalmol.2013.4014.
Conflict of Interest Disclosures: None reported.
Funding/Support: Financial support from Fight for Sight is gratefully acknowledged. Dr Gardner is supported by a Physician Scientist Award from Research to Prevent Blindness and a Taubman Scholar.
Additional Contributions: We thank John Chen, MD, for insight into FAF analysis; Paul Lee, MD, JD, and David Musch, PhD, MPH, for critical appraisal; Shahzad Mian, MD, and Jill Bixler, MD, for recruiting subjects; Kari Branham, MS, CGC; Richard Hackel, MA, CRA, FOPS, Rob Prusak, CRA, Lin Goings, CRA, and Hilary Bernard, CRA, for fundus imaging; and Michelle Cote, MSE, and Anthony Leithauser, BSE, for technical advice.