Submitted for Publication: March 28, 2013; final revision received April 1, 2013; accepted April 1, 2013.
Author Contributions:Study concept and design: Mitchell, Bressler, Tolley, Gallagher, Ferreira, Bandello.
Acquisition of data: Mitchell, Tolley.
Analysis and interpretation of data: All authors.
Drafting of the manuscript: Mitchell, Bressler, Tolley, Petrillo, Ferreira, Wood.
Critical revision of the manuscript for important intellectual content: Mitchell, Bressler, Tolley, Gallagher, Petrillo, Ferreira, Bandello.
Statistical analysis: Tolley, Gallagher, Petrillo, Ferreira, Wood.
Obtained funding: Mitchell.
Administrative, technical, and material support: Mitchell, Tolley, Petrillo, Ferreira.
Study supervision: Mitchell, Bandello.
Published Online: August 22, 2013. doi:10.1001/jamaophthalmol.2013.4592.
Conflict of Interest Disclosures: Dr Mitchell reported receiving consultancy fees, lecture fees, and travel support from Novartis Pharma AG, Pfizer, Solvay (Abbott), Bayer, Alcon, and Allergan. Novartis Pharma AG also funds a retina fellowship at Westmead Hospital, Sydney, which Dr Mitchell reported serving as supervisor. Dr Bressler reported serving as principal investigator of grants at The Johns Hopkins University sponsored by the following entities (not including the National Institutes of Health): Bayer, Genentech Inc, Lumenis Inc, National Eye Institute, Notal Vision, Novartis Pharma AG, Optovue, Regeneron Pharmaceuticals Inc, and The EMMES Corporation. Messers Tolley and Wood reported receiving consultant fees by Novartis Pharma AG to analyze these data. Ms Gallagher reports being a former employee of Novartis Pharma AG, Basel, Switzerland, and currently employed by Sanofi, Cambridge, Massachusetts. Drs Petrillo and Ferreira report being employees of Novartis Pharma AG. Dr Bandello reports serving as an advisory board member for Alcon, Inc, Alimera Sciences, Inc, Allergan, Inc, Bausch and Lomb, Bayer Schering Pharma, Farmila-Thea, Genentech, Inc, Hoffmann-LaRoche, Ltd, Pfizer Inc, Novartis Pharmaceuticals Corporation, sanofi-aventis, and Thrombogenics, Inc.
Group Information: The RESTORE study group members include Alfredo Adan Civera, MD, Barcelona, Spain; Cezmi Akkin, MD, Izmir, Turkey; Clare Bailey, MD, Bristol, United Kingdom; Emilio Balestrazzi, MD, Rome, Italy; Nicholas Beare, MD, Liverpool, United Kingdom; Arpad Berecki, PhD, Györ, Hungary; Andras Berta, MD, PhD, Debrecen, Hungary; Shelley Boyd, MD, Toronto, Ontario, Canada; Periklis Brazitikos, MD, PhD, Thessaloniki, Greece; Enrique Cervera, MD, Valencia, Spain; John Chen, MD, Montreal, Quebec, Canada; Catherine Creuzot-Garcher, MD, PhD, Dijon, France; Nicola Delle Noci, MD, Foggia, Italy; Marlene Devriendt, MD, Jette, Belgium; Stavros Dimitrakos, MD, PhD, Thessaloniki, Greece; Bora Eldem, MD, Ankara, Turkey; Karl-Heinz Emmerich, MD, Darmstadt, Germany; Katrin Engelmann, MD, PhD, Chemnitz, Germany; Mehmet Ergin, MD, Izmir, Turkey; Johannes Fleischhauer, MD, Bern, Switzerland; Josep Garcia-Arumi, MD, Barcelona, Spain; Justus Garweg, MD, Bern, Switzerland; Heinrich Gerding, MD, Olten, Switzerland; Mark Gillies, MBBS, PhD, Sydney, Australia; Francisco Gomez Ulla, MD, PhD, Santiago de Compostela, Spain; John Gonder, MD, London, Ontario, Canada, Salvatore Grisanti, MD, Lübeck, Germany; Lutz L. Hansen, MD, PhD, Freiberg, Germany; Berati Hasanreisoglu, MD, Ankara, Turkey; Helmut Hoeh, MD, FEBO, Neubrandenburg, Germany; Frank G. Holz, MD, Bonn, Germany; Vergados Ioaanis, MD, PhD, Athens, Greece; Antonia Joussen, MD, PhD, Duesseldorf, Germany; Stamatina Kabanarou, MD, PhD, Athens, Greece; Anselm Kampik, MD, Muenchen, Germany; Ziya Kapran, MD, Istanbul, Turkey; Ulrich Kellner, MD, Siegburg, Germany; Agnes Kerényi, MD, PhD, Budapest, Hungary; Peter Kertes, MD, FRCS, Toronto, Ontario, Canada; Bernd Kirchhof, MD, Koeln, Germany; B. J. Klevering, MD, PhD, Nijmegen, the Netherlands; Patrik Kloos, MD, FEBO, St Gallen, Switzerland; Vladimir Kozousek, MD, Halifax, Nova Scotia, Canada; Malaika Kurz-Levin, MD, Zurich, Switzerland; Gabriele E. Lang, MD, Ulm, Germany; David Maberley, MD, Vancouver, British Columbia, Canada; J. P. Martinez Ciriano, MD, Rotterdam, the Netherlands; Pascale Massin, MD, PhD, Paris, France; Ugo Menchini, MD, Firenze, Italy; Geeta Menon, Frimley, United Kingdom; Paul Mitchell, MD, PhD, Westmead, Australia; Andreas Mohr, MD, Bremen, Germany; Sebastien Olivier, MD, Montreal, Quebec, Canada; Andras Papp, MD, PhD, Budapest, Hungary; Alfredo Reibaldi, MD, PhD, Catania, Italy; Jean-Paul Romanet, MD, Grenoble, France; Jose M. Ruiz Moreno, MD, PhD, Alicante, Spain; Carlo Sborgia, MD, Bari, Italy; R. O. Schlingemann, MD, PhD, Amsterdam, the Netherlands; Ursula Schmidt-Erfurth, MD, Vienna, Austria; Ulrike Schneider, MD, Basel, Switzerland; Norbert Schrage, MD, Koeln, Germany, Andras I. Seres, MD, Budapest, Hungary; Dianne Sharp, MD, Auckland, New Zealand; Christian Simader, MD, Vienna, Austria; Gungor Sobaci, MD, Etlik/Ankara, Turkey; Georg Spital, MD, Meunster, Germany; Florian Sutter, MD, Zurich, Switzerland; Christoph Tappeiner, MD, Bern, Switzerland; Anna Tarantini, MD, Udine, Italy; Miltiadis Tsilibaris, MD, Heraklion/Crete, Greece; Ramon Torrez Imaz, MD, Madrid, Spain; Joachim Van Calster, MD, Leuven, Belgium; Brendan Vote, MD, MBBS, Launceston, Australia; Michel Weber, MD, PhD, Nantes, France; Peter Wiedemann, MD, Leipzig, Germany; Tien Wong, MD, PhD, Melbourne, Australia.
Additional Contributions: Daniel Shaw, BSc, (formerly of the Adelphi Group) provided statistical support. Polly Field, DPhil (Oxford PharmaGenesis Ltd), Rumjhum Agrawal , and Hareesh Cheela provided technical assistance, and Emma Boulton (Tolley Health Economics) provided administrative support in preparation of the manuscript.
Correction: This article was corrected on November 14, 2013, to fix Table 1, Figures 2 and 3, and the text.