Little is known about the association of cutaneous vitiligo with uveal melanoma. In this retrospective study, Rishi and colleagues found 6 of 4760 patients with uveal melanoma developing vitiligo over a mean of 77 months. Treatment included observation, plaque radiotherapy, and enucleation. Vitiligo developed bilaterally with multiple well-defined lesions, affecting 5% to 40% of body surface, generally in the upper body. At a mean of 71 months’ follow-up, there was no local tumor recurrence.