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Case Report/Case Series |

Noncontact High-Resolution Ultra–Wide-Field Oral Fluorescein Angiography in Premature Infants With Retinopathy of Prematurity

Timothy H. M. Fung, MBChB1; Mahiul M. K. Muqit, FRCOphth1; David J. Mordant, FRCOphth1; Lewis M. Smith, BA1; Chetan K. Patel, FRCOphth1
[+] Author Affiliations
1Vitreoretinal Service, Oxford Eye Hospital, John Radcliffe Hospital, Oxford, England
JAMA Ophthalmol. 2014;132(1):108-110. doi:10.1001/jamaophthalmol.2013.6102.
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Importance  We report for the first time, to our knowledge, the acquisition of noncontact ultra–wide-field oral fluorescein angiograms in premature infants with retinopathy of prematurity.

Observations  High-resolution oral fluorescein angiograms were successfully obtained in 3 consecutive premature infants with retinopathy of prematurity at the Oxford Eye Hospital, Oxford, England, using the Optos Panoramic 200MA imaging system (Optos PLC).

Conclusions and Relevance  Noncontact ultra–wide-field oral fluorescein angiograms captured using the Optos Panoramic 200MA fluorescein angiographic system provide a safe and alternative method for evaluating the retinal vasculature in premature infants with retinopathy of prematurity.

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Figure 1.
Imaging Process With the Optos Panoramic 200MA

The premature infant is held in the “flying baby” position and images are captured when the pupil is appropriately aligned with the camera lens.

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Figure 2.
Ultra–Wide-Field Images Acquired in Case 1

A and B, Ultra–wide-field color fundus photographs of the infant demonstrate stage 3 zone 2 retinopathy of prematurity with pre–plus disease in both eyes. C and D, Ultra–wide-field oral fluorescein angiograms reveal obvious leakage at areas of neovascularization in both eyes.

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Figure 3.
Ultra–Wide-Field Images Acquired in Case 2

A, Ultra–wide-field color fundus photograph of the right eye reveals stage 3 posterior zone 2 retinopathy of prematurity with plus disease. B, A single fluorescein angiogram reveals more than 180° of neovascularization.

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Figure 4.
Ultra–Wide-Field Images Acquired in Case 3

A, Ultra–wide-field color fundus photograph demonstrates stage 3 zone 2 retinopathy of prematurity with plus disease. B, Ultra–wide-field oral fluorescein angiogram clearly shows the isolated neovascular tuft as well as the zone of neovascularization.

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