Submitted for Publication: January 12, 2013; final revision received April 2, 2013; accepted June 16, 2013.
Published Online: November 21, 2013. doi:10.1001/jamaophthalmol.2013.6022.
Study concept and design: Hysi, Young, Mackey, Hammond.
Acquisition of data: Hysi, Cumberland, Young, Mackey, Rahi, Hammond.
Analysis and interpretation of data: Hysi, Mahroo, Cumberland, Wojciechowski, Williams, Hammond.
Drafting of the manuscript: Hysi, Hammond.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Hysi, Cumberland, Wojciechowski.
Obtained funding: Young, Mackey, Rahi, Hammond.
Administrative, technical, or material support: Hysi, Mahroo, Williams, Mackey, Hammond.
Study supervision: Rahi, Hammond.
Conflict of Interest Disclosures: None reported.
Funding/Support: Phenotyping for the 1958 British Birth Cohort was funded by the Medical Research Council Health of the Public grant (principal investigators, C. Power, PhD, and D. P. Strachan, MD) and the genetic studies, by the Wellcome Trust (grant 083478 to Dr Rahi), with additional personal funding (Dr Hysi) by the Ulverscroft Vision Research Group. The Centre for Paediatric Epidemiology and Biostatistics was supported in part by the Medical Research Council in its capacity as the MRC Centre of Epidemiology for Child Health. Research at the UCL Institute of Child Health, Great Ormond Street Hospital for Children, Moorfields Eye Hospital NHS Foundation Trust, and UCL Institute of Ophthalmology receives a proportion of their funding from the National Institute for Health Research Biomedical Research Centres funding scheme. TwinsUK received funding from the Wellcome Trust; the European Union MyEuropia Marie Curie Research Training Network; Guide Dogs for the Blind Association; the European Community’s FP7 (grant HEALTHF22008201865GEFOS); ENGAGE (grant HEALTHF42007201413); the FP-5 GenomEUtwin Project (grant QLG2CT200201254); US National Institutes of Health/National Eye Institute (grant 1RO1EY018246, principal investigator, T. L. Young, MD); NIH Center for Inherited Disease Research; and the National Institute for Health Research comprehensive Biomedical Research Centre award to Guy’s and St Thomas’ National Health Service Foundation Trust partnering with King’s College London. Dr Hysi is the recipient of a Fight for Sight ECI award. Dr Williams acknowledges financial support from the TFC Frost Charitable Trust. Dr Mahroo is a recipient of the Fight for Sight New Lecturers’ Grant Award.
Role of the Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Disclaimer: The views expressed are those of the authors and not necessarily those of the National Health Service, the National Institute for Health Research, or the Department of Health.