We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editorial |

Evidence for Including Lutein and Zeaxanthin in Oral Supplements for Age-Related Macular Degeneration

David C. Musch, PhD, MPH1
[+] Author Affiliations
1Departments of Ophthalmology and Visual Sciences and Epidemiology, University of Michigan, Ann Arbor
JAMA Ophthalmol. 2014;132(2):139-141. doi:10.1001/jamaophthalmol.2013.7443.
Text Size: A A A
Published online


In a National Eye Institute press release1 issued on May 5, 2013, with simultaneous online publication in JAMA,2 the results from the second phase of the Age-Related Eye Disease Study 2 (AREDS2) were announced. This press release was titled “NIH study provides clarity on supplements for protection against blinding eye disease,” and indeed in its first paragraph, the primary outcome was clearly stated: “The plant-derived antioxidants lutein and zeaxanthin also had no overall effect on [age-related macular degeneration (AMD)] when added to the combination; however, they were safer than the related antioxidant beta-carotene.” This study provided us with a striking example of a major clinical trial in which the primary outcome was negative, but yet its broader findings prompted substantial changes in the formulation of so-called eye vitamins that constitute a major market presence and are likely recommended by most eye care practitioners for a patient they determine to be at risk for developing neovascular AMD. The ability of companies to market their eye vitamins as providing an exact match to the AREDS2 formula is evidently important because we encounter such statements in venues ranging from our professional journals to television commercials. While some might say that the train has long since left the station, the purpose of this editorial is to critically evaluate the evidence underlying formulation changes that are under way or have already taken place.

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

14 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles