Group Information: The AREDS2 Research Group is found online in the Supplement (eAppendix 2).
Submitted for Publication: June 18, 2013; final revision received October 23, 2013; accepted October 29, 2013.
Published Online: December 5, 2013. doi:10.1001/jamaophthalmol.2013.7376.
Study concept and design: Chew, SanGiovanni, Danis, Ferris, Elman, Chandra, Friberg, Sperduto.
Acquisition of data: Danis, Elman, Antoszyk, Ruby, Bressler, Fish, Hubbard, Klein, Chandra, Blodi, Domalpally, Friberg, Wong, Rosenfeld, Toth, Bernstein.
Analysis and interpretation of data: Chew, Clemons, Danis, Ferris, Elman, Antoszyk, Orth, Bressler, Blodi, Domalpally, Friberg, Wong, Rosenfeld, Agrón, Bernstein, Sperduto.
Drafting of the manuscript: Chew, Clemons, SanGiovanni, Bressler, Friberg, Rosenfeld, Agrón.
Critical revision of the manuscript for important intellectual content: Chew, Clemons, Danis, Ferris, Elman, Antoszyk, Ruby, Orth, Fish, Hubbard, Klein, Chandra, Blodi, Domalpally, Friberg, Wong, Rosenfeld, Agrón, Toth, Bernstein, Sperduto.
Statistical analysis: Clemons, Friberg, Agrón, Sperduto.
Obtained funding: Chew, Ferris, Blodi.
Administrative, technical, or material support: Chew, Danis, Ferris, Elman, Antoszyk, Ruby, Klein, Chandra, Domalpally, Sperduto.
Study supervision: Chew, Clemons, SanGiovanni, Danis, Ferris, Elman, Bressler, Friberg, Wong, Toth.
Conflict of Interest Disclosures: Dr Ferris holds a patent for the Age-Related Eye Disease Study (AREDS) formulation with Bausch and Lomb and also receives royalties. Dr Antoszyk receives grant and travel support from Southwest Clinical Research Associates LLC. Dr Ruby receives payment for lectures from Genentech. Dr Bressler receives grant and travel support from Emmes Corp and the Jaeb Center; received a physician-scientist grant from Research to Prevent Blindness; serves as a consultant for GlaxoSmithKline; receives grants or grants pending from Allergan, Bayer Healthcare, Genentech, Lumenis Inc, Notal Vision Ltd, Novartis, Regeneron, Thrombogenics, and Sanofi-Aventis; received payment for lectures from providers of continuing medical education materials; and served as an investigator on a grant to Johns Hopkins University sponsored by Bausch and Lomb (this grant was negotiated and administered by the School of Medicine, which receives the grant through the Office of Research Administration [individual investigators who participate in such sponsored projects are not directly compensated by the sponsor but may receive salary or other support from the institution to support their effort on the projects]). Dr Fish has received grant and travel support from Texas Retina Associates. Dr Rosenfeld has served as a consultant for Oraya, Novartis, Chengdu Kanghong Biotech, Acucela, Thrombogenics, and Canon; has received grants or grants pending from Carl Zeiss Meditec, Alexion, Potentia, and GlaxoSmithKline; and has received payment for lectures from Carl Zeiss Meditec, Allergan, and Topcon. Dr Toth has received grant and travel support from Emmes Corp and served as a consultant to ALCON for surgical technologies and research support for Genentech. Dr Bernstein has served as a consultant for Kemin Health, Kalsec, DSM, and Science Based Health. No other disclosures were reported.
Funding/Support: This study was supported by the intramural program funds and contracts from the National Eye Institute/National Institutes of Health (NEI/NIH), Department of Health and Human Services, Bethesda, Maryland (contract No. HHS-N-260-2005-00007-C and ADB contract No. N01-EY-5-0007). Funds were contributed to these contracts by the following NIH institutes: Office of Dietary Supplements, National Center for Complementary and Alternative Medicine, National Institute on Aging, National Heart, Lung and Blood Institute, and National Institute of Neurological Disorders and Stroke. The study medications and raw materials were provided by Alcon, Bausch and Lomb, DSM, and Pfizer.
Role of the Sponsor: The funding agencies had no role in the design and conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.