Submitted for Publication: May 20, 2013; final revision received October 4, 2013; accepted October 16, 2013.
Published Online: December 12, 2013. doi:10.1001/jamaophthalmol.2013.7288.
Study concept and design: Yiu, Farsiu, Mruthyunjaya.
Acquisition of data: Yiu, Pecen, Sarin, Toth.
Analysis and interpretation of data: Yiu, Sarin, Chiu, Farsiu, Toth.
Drafting of the manuscript: Yiu.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Yiu.
Obtained funding: Sarin, Toth.
Administrative, technical, or material support: Yiu, Sarin, Farsiu, Mruthyunjaya.
Study supervision: Farsiu, Mruthyunjaya, Toth.
Conflict of Interest Disclosures: Dr Toth receives royalties through her university from Alcon and obtained research support through her university from Bioptigen, Genentech, and Physical Sciences Inc. Drs Toth and Farsiu and Ms Chiu have patents pending in OCT imaging and analysis. The A2A-SDOCT study (ClinicalTrials.gov identifier NCT00734487) was funded in part by a grant from Genentech through Duke University, which was conferred prior to the study presented in this manuscript.
Funding/Support: Dr Yiu is supported in part by the Heed Ophthalmic Foundation.
Role of the Sponsor: The funders had no role in the design and conduct of this study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank Alan D. Proia, MD, PhD (Duke University Eye Center), for assistance with histological analysis of postmortem eyes, Sandra Stinnett, PhD (Duke University Eye Center), for assistance with statistics, and Melody Y. Hou, MD, MPH (University of California, Davis School of Medicine), for review of the manuscript.