Submitted for Publication: May 16, 2013; final revision received July 10, 2013; accepted July 26, 2013.
Published Online: December 19, 2013. doi:10.1001/jamaophthalmol.2013.6426.
Study concept and design: Bressler, Varma, Doan, Danese, Selvin, Dolan, Fine, Colman, Turpcu.
Acquisition of data: Doan, Danese, Selvin, Turpcu.
Analysis and interpretation of data: Bressler, Varma, Doan, Gleeson, Danese, Bower, Selvin, Dolan, Colman, Turpcu.
Drafting of the manuscript: Bressler, Doan, Selvin, Dolan, Fine.
Critical revision of the manuscript for important intellectual content: Bressler, Varma, Doan, Gleeson, Danese, Bower, Selvin, Dolan, Colman, Turpcu.
Statistical analysis: Doan, Gleeson, Danese, Bower, Selvin.
Obtained funding: Bressler, Doan, Danese.
Administrative, technical, and material support: Varma, Doan, Danese, Dolan, Colman.
Study supervision: Bressler, Varma, Selvin, Fine, Colman, Turpcu.
Conflict of Interest Disclosures: Dr Bressler is principal investigator of grants at The Johns Hopkins University sponsored by Bausch & Lomb Incorporated, ForSight Labs, LLC, Genentech, Inc, Genzyme Corporation, Lumenis Inc, Notal Vision, Novartis Pharma AG, Optovue, Inc, and Regeneron Pharmaceuticals, Inc, and not including the National Institutes of Health. Dr Varma is a consultant for Allergan, Aquesys, Genentech, Inc, Merck, and Replenish and has received research funding from Genentech, Inc, and Replenish. Drs Doan, Gleeson, and Danese are employees of Outcomes Insights, Inc, and paid consultants for Genentech, Inc. Drs Bower and Selvin are coinvestigators supported by Dr Bressler’s grant at The Johns Hopkins University sponsored by Genentech, Inc. Dr Dolan is a paid consultant for Genentech, Inc. Drs Fine, Colman, and Turpcu are employees of Genentech, Inc.
Funding/Support: This study was supported by a grant from Genentech, Inc, and Roche to The Johns Hopkins University through the Office of Research Administration of the Johns Hopkins University School of Medicine. Support for third-party writing assistance for this manuscript, provided by Rebecca Jarvis, PhD, CMPP, of Envision Scientific Solutions, was provided by Genentech Inc.
Role of the Sponsors: Genentech, Inc, and Roche employees participated in the design of the study, in the revision of the manuscript, and had access to the data before the completion of data analysis but did not participate in the statistical analysis. The Johns Hopkins University School of Public Health investigators independently replicated and verified all analyses.
Disclaimer: Dr Bressler is the Editor of JAMA Ophthalmology. He was not involved in the editorial evaluation or decision to accept this article for publication.
Previous Presentations: Portions of these data were presented at the Retina Society Annual Meeting; September 28, 2012; Washington, DC; at the Macula Society Annual Meeting; March 1, 2013; Dana Point, California; and at the American Academy of Optometry Annual Meeting; October 24, 2012; Phoenix, Arizona.
Additional Contributions: An independent statistical analysis, used for all data provided in the report, was conducted by the Johns Hopkins University Bloomberg School of Public Health faculty (Drs Bower and Selvin). Additional statistical analysis was performed by Outcomes Insights, Inc (Drs Doan and Gleeson). Rebecca Jarvis, PhD, CMPP, of Envision Scientific Solutions, provided editorial assistance and was compensated by Genentech, Inc.