How will the journal strive for prompt review of submissions and publication? The review process has been revised such that each properly submitted manuscript is forwarded to 1 or more of the senior editors to assess the manuscript’s quality and its priority for publication. A manuscript in which the subject matter does not meet the current editorial priorities of JAMA Ophthalmology or is judged unlikely to succeed through stringent external review is rejected at that point, typically within a week. This process allows an author to submit the manuscript to another journal without the delay entailed by a more formal review process, thus serving one of the author’s ultimate goals, rapid review. Currently, approximately one-third of the submissions go on to additional peer review, which is to be completed within 2 weeks. In this way, a peer reviewer can concentrate her or his time on evaluating a manuscript and provide a review that either indicates that a paper cannot be revised sufficiently to warrant publication, and therefore should be rejected, or accepted as is, or modified based on objective, independent recommendations that likely will lead to an improved manuscript and eventual publication. If a reviewer is unable to complete the review promptly, then 1 or more of the editorial board members or their designate is asked to complete the review within a week. In this way, all reviews should be completed no later than 1 month following submission. After a decision is made to go forward with a revision, authors then are asked to provide their revisions within a month. If these revisions adequately address the editor’s and the reviewers’ comments, a manuscript typically can be accepted for publication within a week of resubmission, unless additional review is warranted. JAMA Ophthalmology, as part of The JAMA Network, is committed to publishing accepted major articles online within 60 days of acceptance. For major clinical trials that likely have substantial public health importance or that may change practice, even faster publication schedules can be accomplished with advanced notice, indicating the ability to time the online publication with meeting presentations.