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Comment & Response |

Regarding Macular Xanthophylls and ω-3 Long-Chain Polyunsaturated Fatty Acids in Age-Related Macular Degeneration—Reply

Christin Arnold, Dipl-Troph1; Susanne Jentsch, Dipl-Ing2; Dietrich Schweitzer, PhD2; Volker Böhm, PhD1
[+] Author Affiliations
1Institute of Nutrition, Friedrich Schiller University Jena, Jena, Germany
2University Eye Hospital, Jena, Germany
JAMA Ophthalmol. 2014;132(2):231-232. doi:10.1001/jamaophthalmol.2013.6340.
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In Reply We appreciate the interest and the comments written by Meagher et al regarding our study and the methods used.

Lutein and zeaxanthin concentrations in the plasma of patients with AMD were analyzed via normal-phase high-performance liquid chromatography using an NH2 column at 40°C. We searched for a carotenoid, which occurs only in traces in plasma. Furthermore, its peak should be adequately distinguishable from the other peaks in the method used. Astaxanthin ([3S,3′S]-3,3′-dihydroxy-β,β-carotene-4,4′-dione) met these requirements. In random checks, the concentrations of astaxanthin in the plasma of the participants were well below the limit of quantification. Besides that, astaxanthin is structurally related to lutein and zeaxanthin and therefore exhibits a similar behavior against outside influences during sample preparation. Additionally, the participants were instructed to abstain from dietary supplements. Those reporting a consumption of supplements were excluded from the study.


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February 1, 2014
Katherine A. Meagher, BSc; John M. Nolan, PhD; Stephen Beatty, MD, FRCOphth
1Department of Chemical and Life Sciences, Macular Pigment Research Group, Waterford Institute of Technology, Waterford, Ireland
JAMA Ophthalmol. 2014;132(2):230-231. doi:10.1001/jamaophthalmol.2013.6667.
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