Submitted for Publication: June 28, 2013; final revision received November 1, 2013; accepted November 16, 2013.
Published Online: March 6, 2014. doi:10.1001/jamaophthalmol.2014.93.
Study concept and design: Scott, Jackson, Liao, Gardner.
Acquisition, analysis, or interpretation of data: Quillen, Larsen, Klein, Holfort, Munch, Gardner.
Analysis and interpretation of data: Scott, Jackson, Liao, Gardner.
Drafting of the manuscript: Scott, Jackson, Liao, Gardner.
Critical revision of the manuscript for important intellectual content: Jackson, Quillen, Larsen, Klein, Holfort, Munch, Gardner.
Statistical analysis: Jackson, Larsen, Liao.
Obtained funding: Holfort, Gardner.
Administrative, technical, or material support: Scott, Jackson, Quillen, Larsen, Holfort, Munch, Gardner.
Study supervision: Jackson, Larsen, Klein, Holfort.
Conflict of Interest Disclosures: Dr Jackson is an investor and employee of MacuLogix, Inc, Hershey, Pennsylvania, the manufacturer of the AdaptDx. No other disclosures were reported.
Funding/Support: The trial was supported in part by grant 4-2007-231 from the Juvenile Diabetes Research Foundation, a Research to Prevent Blindness Physician-Scientist Award, and the A. Alfred Taubman Medical Research Institute (Dr Gardner).
Role of the Sponsor: The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Maria Emanuel Ryan, DDS, PhD, of Stony Brook University, Stony Brook, New York, and Steve Levison, PhD, of Rutgers University–New Jersey Medical School, Newark, provided helpful discussions regarding the anti-inflammatory effects of tetracyclines in persons with diabetes. Steven F. Abcouwer, PhD, of the University of Michigan Kellogg Eye Center, Ann Arbor, provided helpful suggestions for the article. None of these individuals received financial compensation for their services.