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Comment & Response |

Cataracts and Statin Use Cause and Effect Not Confirmed

Timo E. Strandberg, MD, PhD1,2,3; Ahti Tarkkanen, MD, PhD2,3
[+] Author Affiliations
1Institute of Health Sciences/Geriatrics, University of Oulu, Oulu, Finland
2Geriatric Clinic, Department of Medicine, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland
3Department of Ophthalmology, Helsinki University Central Hospital, Helsinki, Finland
JAMA Ophthalmol. 2014;132(3):365. doi:10.1001/jamaophthalmol.2014.23.
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To the Editor We read with great interest the article titled “Association of Statin Use With Cataracts: A Propensity Score–Matched Analysis” by Leuschen et al,1 but we fear that their conclusions of statins and cataract risk are not at all justified if totality of evidence is taken into account. The analysis was based on a large database (n = 46 249 patients) of a military health care system and suggested a 9% to 27% increased risk for cataract among statin users as compared with nonusers. Although the authors carefully adjusted for a number of contemporary confounders, we assume that the diagnosis of cataract was necessarily based on medical records and not on a standardized diagnostic protocol.

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March 1, 2014
Barbara E. K. Klein, MD, MPH; Kristine E. Lee, MS; Ronald Klein, MD, MPH
1Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin–Madison, Madison
JAMA Ophthalmol. 2014;132(3):366-367. doi:10.1001/jamaophthalmol.2014.225.
March 1, 2014
Ishak Mansi, MD; Jessica Leuschen, MD; Eric M. Mortensen, MD, MSc
1VA North Texas Health Care System, Dallas2Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas3Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas
4Wilford Hall Ambulatory Surgery Center, San Antonio, Texas5San Antonio Military Medical Center, San Antonio, Texas
JAMA Ophthalmol. 2014;132(3):365-366. doi:10.1001/jamaophthalmol.2014.75.
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