Submitted for Publication: June 4, 2013; final revision received December 2, 2013; accepted December 19, 2013.
Published Online: March 20, 2014. doi:10.1001/jamaophthalmol.2013.8179.
Study concept and design: Suhler, Lim, Smith, Rosenbaum.
Acquisition, analysis, or interpretation of data: Suhler, Lim, Giles, Pasadhika, Lee, de Saint Sardos, Butler, Rosenbaum.
Analysis and interpretation of data: Suhler, Lim, Beardsley, Pasadhika, de Saint Sardos, Butler, Rosenbaum.
Drafting of the manuscript: Suhler, Beardsley, Giles.
Critical revision of the manuscript for important intellectual content: Suhler, Lim, Pasadhika, Lee, de Saint Sardos, Butler, Smith, Rosenbaum.
Statistical analysis: Suhler.
Obtained funding: Suhler, Rosenbaum.
Administrative, technical, or material support: Lim, Beardsley, Giles, Pasadhika, Lee, de Saint Sardos, Butler, Rosenbaum.
Study supervision: Suhler, Rosenbaum.
Conflict of Interest Disclosures: Dr Suhler has served as a paid consultant to Lux Bio, Abbott/AbbVie, and Eleven Biotherapeutics. Dr Lim has served as a paid consultant to Bayer. Dr Rosenbaum has served as a paid consultant to Amgen, Lux Bio, Xoma, Centocor, Genentech, Pfizer, Santen, Teva, sanofi-aventis, Regeneron, Elan, Celtic Therapeutics, Mitotech, and Abbott/AbbVie. The Oregon Health and Science University Uveitis Clinic has received research support from Abbott/AbbVie, Bristol-Myers Squibb, EyeGate, LuxBio, and Novartis. No other disclosures were reported.
Funding/Support: Study expenses and drug were provided by Genentech, San Francisco, California. Additional research support was provided by the Department of Veterans’ Affairs (Dr Suhler), Research to Prevent Blindness (unrestricted grant to Casey Eye Institute, Senior Scholar Award to Dr Rosenbaum), the Rosenfeld Family Trust (Dr Rosenbaum), and the William and Mary Bauman Foundation.
Role of the Sponsor: The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication, but Genentech reviewed the manuscript prior to submission.
Previous Presentations: This study was presented in part at the 2008, 2009, 2010, and 2011 Meetings of the Association for Research in Vision and Ophthalmology; May 2008; May 2009; May 4, 2010; and May 5, 2011; all in Fort Lauderdale, Florida.
Additional Contributions: Russell Van Gelder, MD, PhD, University of Washington, provided assistance with enrollment of the participants. Dr Van Gelder received no financial compensation for his work.